List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Waist-hip ratio. The EFO term waist-hip ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
IM Heid, AU Jackson, JC Randall, TW Winkler, L Qi, V Steinthorsdottir, G Thorleifsson, MC Zillikens, EK Speliotes, R Mägi, T Workalemahu, CC White, N Bouatia-Naji, TB Harris, SI Berndt, E Ingelsson, CJ Willer, MN Weedon, J Luan, S Vedantam, T Esko, TO Kilpeläinen, Z Kutalik, S Li, KL Monda, AL Dixon, CC Holmes, LM Kaplan, L Liang, JL Min, MF Moffatt, C Molony, G Nicholson, EE Schadt, KT Zondervan, MF Feitosa, T Ferreira, H Lango Allen, RJ Weyant, E Wheeler, AR Wood, K Estrada, ME Goddard, G Lettre, M Mangino, DR Nyholt, S Purcell, AV Smith, PM Visscher, J Yang, SA McCarroll, J Nemesh, BF Voight, D Absher, N Amin, T Aspelund, L Coin, NL Glazer, C Hayward, NL Heard-Costa, JJ Hottenga, A Johansson, T Johnson, M Kaakinen, K Kapur, S Ketkar, JW Knowles, P Kraft, AT Kraja, C Lamina, MF Leitzmann, B McKnight, AP Morris, KK Ong, JR Perry, MJ Peters, O Polasek, I Prokopenko, NW Rayner, S Ripatti, F Rivadeneira, NR Robertson, S Sanna, U Sovio, I Surakka, A Teumer, S van Wingerden, V Vitart, JH Zhao, C Cavalcanti-Proença, PS Chines, E Fisher, JR Kulzer, C Lecoeur, N Narisu, C Sandholt, LJ Scott, K Silander, K Stark, ML Tammesoo, TM Teslovich, NJ Timpson, RM Watanabe, R Welch, DI Chasman, MN Cooper, JO Jansson, J Kettunen, RW Lawrence, N Pellikka, M Perola, L Vandenput, H Alavere, P Almgren, LD Atwood, AJ Bennett, R Biffar, LL Bonnycastle, SR Bornstein, TA Buchanan, H Campbell, IN Day, M Dei, M Dörr, P Elliott, MR Erdos, JG Eriksson, NB Freimer, M Fu, S Gaget, EJ Geus, AP Gjesing, H Grallert, J Grässler, CJ Groves, C Guiducci, AL Hartikainen, N Hassanali, AS Havulinna, KH Herzig, AA Hicks, J Hui, W Igl, P Jousilahti, A Jula, E Kajantie, L Kinnunen, I Kolcic, S Koskinen, P Kovacs, HK Kroemer, V Krzelj, J Kuusisto, K Kvaloy, J Laitinen, O Lantieri, GM Lathrop, ML Lokki, RN Luben, B Ludwig, WL McArdle, A McCarthy, MA Morken, M Nelis, MJ Neville, G Paré, AN Parker, JF Peden, I Pichler, KH Pietiläinen, CG Platou, A Pouta, M Ridderstråle, NJ Samani, J Saramies, J Sinisalo, JH Smit, RJ Strawbridge, HM Stringham, AJ Swift, M Teder-Laving, B Thomson, G Usala, JB van Meurs, GJ van Ommen, V Vatin, CB Volpato, H Wallaschofski, GB Walters, E Widen, SH Wild, G Willemsen, DR Witte, L Zgaga, P Zitting, JP Beilby, AL James, M Kähönen, T Lehtimäki, MS Nieminen, C Ohlsson, LJ Palmer, O Raitakari, PM Ridker, M Stumvoll, A Tönjes, J Viikari, B Balkau, Y Ben-Shlomo, RN Bergman, H Boeing, GD Smith, S Ebrahim, P Froguel, T Hansen, C Hengstenberg, K Hveem, B Isomaa, T Jørgensen, F Karpe, KT Khaw, M Laakso, DA Lawlor, M Marre, T Meitinger, A Metspalu, K Midthjell, O Pedersen, V Salomaa, PE Schwarz, T Tuomi, J Tuomilehto, TT Valle, NJ Wareham, AM Arnold, JS Beckmann, S Bergmann, E Boerwinkle, DI Boomsma, MJ Caulfield, FS Collins, G Eiriksdottir, V Gudnason, U Gyllensten, A Hamsten, AT Hattersley, A Hofman, FB Hu, T Illig, C Iribarren, MR Jarvelin, WH Kao, J Kaprio, LJ Launer, PB Munroe, B Oostra, BW Penninx, PP Pramstaller, BM Psaty, T Quertermous, A Rissanen, I Rudan, AR Shuldiner, N Soranzo, TD Spector, AC Syvanen, M Uda, A Uitterlinden, H Völzke, P Vollenweider, JF Wilson, JC Witteman, AF Wright, GR Abecasis, M Boehnke, IB Borecki, P Deloukas, TM Frayling, LC Groop, T Haritunians, DJ Hunter, RC Kaplan, KE North, JR O'Connell, L Peltonen, D Schlessinger, DP Strachan, JN Hirschhorn, TL Assimes, HE Wichmann, U Thorsteinsdottir, CM van Duijn, K Stefansson, LA Cupples, RJ Loos, I Barroso, MI McCarthy, CS Fox, KL Mohlke, CM Lindgren
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Age-related macular degeneration. The EFO term age-related macular degeneration was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
LG Fritsche, W Chen, M Schu, BL Yaspan, Y Yu, G Thorleifsson, DJ Zack, S Arakawa, V Cipriani, S Ripke, RP Igo, GH Buitendijk, X Sim, DE Weeks, RH Guymer, JE Merriam, PJ Francis, G Hannum, A Agarwal, AM Armbrecht, I Audo, T Aung, GR Barile, M Benchaboune, AC Bird, PN Bishop, KE Branham, M Brooks, AJ Brucker, WH Cade, MS Cain, PA Campochiaro, CC Chan, CY Cheng, EY Chew, KA Chin, I Chowers, DG Clayton, R Cojocaru, YP Conley, BK Cornes, MJ Daly, B Dhillon, AO Edwards, E Evangelou, J Fagerness, HA Ferreyra, JS Friedman, A Geirsdottir, RJ George, C Gieger, N Gupta, SA Hagstrom, SP Harding, C Haritoglou, JR Heckenlively, FG Holz, G Hughes, JP Ioannidis, T Ishibashi, P Joseph, G Jun, Y Kamatani, N Katsanis, C N Keilhauer, JC Khan, IK Kim, Y Kiyohara, BE Klein, R Klein, JL Kovach, I Kozak, CJ Lee, KE Lee, P Lichtner, AJ Lotery, T Meitinger, P Mitchell, S Mohand-Saïd, AT Moore, DJ Morgan, MA Morrison, CE Myers, AC Naj, Y Nakamura, Y Okada, A Orlin, MC Ortube, MI Othman, C Pappas, KH Park, GJ Pauer, NS Peachey, O Poch, RR Priya, R Reynolds, AJ Richardson, R Ripp, G Rudolph, E Ryu, JA Sahel, DA Schaumberg, HP Scholl, SG Schwartz, WK Scott, H Shahid, H Sigurdsson, G Silvestri, TA Sivakumaran, RT Smith, L Sobrin, EH Souied, DE Stambolian, H Stefansson, GM Sturgill-Short, A Takahashi, N Tosakulwong, BJ Truitt, EE Tsironi, AG Uitterlinden, CM van Duijn, L Vijaya, JR Vingerling, EN Vithana, AR Webster, HE Wichmann, TW Winkler, TY Wong, AF Wright, D Zelenika, M Zhang, L Zhao, K Zhang, ML Klein, GS Hageman, GM Lathrop, K Stefansson, R Allikmets, PN Baird, MB Gorin, JJ Wang, CC Klaver, JM Seddon, MA Pericak-Vance, SK Iyengar, JR Yates, A Swaroop, BH Weber, M Kubo, MM Deangelis, T Léveillard, U Thorsteinsdottir, JL Haines, LA Farrer, IM Heid, GR Abecasis
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
E Zeggini, LJ Scott, R Saxena, BF Voight, JL Marchini, T Hu, PI de Bakker, GR Abecasis, P Almgren, G Andersen, K Ardlie, KB Boström, RN Bergman, LL Bonnycastle, K Borch-Johnsen, NP Burtt, H Chen, PS Chines, MJ Daly, P Deodhar, CJ Ding, AS Doney, WL Duren, KS Elliott, MR Erdos, TM Frayling, RM Freathy, L Gianniny, H Grallert, N Grarup, CJ Groves, C Guiducci, T Hansen, C Herder, GA Hitman, TE Hughes, B Isomaa, AU Jackson, T Jørgensen, A Kong, K Kubalanza, FG Kuruvilla, J Kuusisto, C Langenberg, H Lango, T Lauritzen, Y Li, CM Lindgren, V Lyssenko, AF Marvelle, C Meisinger, K Midthjell, KL Mohlke, MA Morken, AD Morris, N Narisu, P Nilsson, KR Owen, CN Palmer, F Payne, JR Perry, E Pettersen, C Platou, I Prokopenko, L Qi, L Qin, NW Rayner, M Rees, JJ Roix, A Sandbaek, B Shields, M Sjögren, V Steinthorsdottir, HM Stringham, AJ Swift, G Thorleifsson, U Thorsteinsdottir, NJ Timpson, T Tuomi, J Tuomilehto, M Walker, RM Watanabe, MN Weedon, CJ Willer, T Illig, K Hveem, FB Hu, M Laakso, K Stefansson, O Pedersen, NJ Wareham, I Barroso, AT Hattersley, FS Collins, L Groop, MI McCarthy, M Boehnke, D Altshuler
GWAS: anthropometric measurement, waist-hip ratio, sexual dimorphism
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sexual dimorphism in anthropometric traits. The EFO term anthropometric measurement, waist-hip ratio, sexual dimorphism was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JC Randall, TW Winkler, Z Kutalik, SI Berndt, AU Jackson, KL Monda, TO Kilpeläinen, T Esko, R Mägi, S Li, T Workalemahu, MF Feitosa, DC Croteau-Chonka, FR Day, T Fall, T Ferreira, S Gustafsson, AE Locke, I Mathieson, A Scherag, S Vedantam, AR Wood, L Liang, V Steinthorsdottir, G Thorleifsson, ET Dermitzakis, AS Dimas, F Karpe, JL Min, G Nicholson, DJ Clegg, T Person, JP Krohn, S Bauer, C Buechler, K Eisinger, A Bonnefond, P Froguel, JJ Hottenga, I Prokopenko, LL Waite, TB Harris, AV Smith, AR Shuldiner, WL McArdle, MJ Caulfield, PB Munroe, H Grönberg, YD Chen, G Li, JS Beckmann, T Johnson, U Thorsteinsdottir, M Teder-Laving, KT Khaw, NJ Wareham, JH Zhao, N Amin, BA Oostra, AT Kraja, MA Province, LA Cupples, NL Heard-Costa, J Kaprio, S Ripatti, I Surakka, FS Collins, J Saramies, J Tuomilehto, A Jula, V Salomaa, J Erdmann, C Hengstenberg, C Loley, H Schunkert, C Lamina, HE Wichmann, E Albrecht, C Gieger, AA Hicks, A Johansson, PP Pramstaller, S Kathiresan, EK Speliotes, B Penninx, AL Hartikainen, MR Jarvelin, U Gyllensten, DI Boomsma, H Campbell, JF Wilson, SJ Chanock, M Farrall, A Goel, C Medina-Gomez, F Rivadeneira, K Estrada, AG Uitterlinden, A Hofman, MC Zillikens, M den Heijer, LA Kiemeney, A Maschio, P Hall, J Tyrer, A Teumer, H Völzke, P Kovacs, A Tönjes, M Mangino, TD Spector, C Hayward, I Rudan, AS Hall, NJ Samani, AP Attwood, JG Sambrook, J Hung, LJ Palmer, ML Lokki, J Sinisalo, G Boucher, H Huikuri, M Lorentzon, C Ohlsson, N Eklund, JG Eriksson, C Barlassina, C Rivolta, IM Nolte, H Snieder, MM Van der Klauw, JV Van Vliet-Ostaptchouk, PV Gejman, J Shi, KB Jacobs, Z Wang, SJ Bakker, I Mateo Leach, G Navis, P van der Harst, NG Martin, SE Medland, GW Montgomery, J Yang, DI Chasman, PM Ridker, LM Rose, T Lehtimäki, O Raitakari, D Absher, C Iribarren, H Basart, KG Hovingh, E Hyppönen, C Power, D Anderson, JP Beilby, J Hui, J Jolley, H Sager, SR Bornstein, PE Schwarz, K Kristiansson, M Perola, J Lindström, AJ Swift, M Uusitupa, M Atalay, TA Lakka, R Rauramaa, JL Bolton, G Fowkes, RM Fraser, JF Price, K Fischer, K Krjutå Kov, A Metspalu, E Mihailov, C Langenberg, J Luan, KK Ong, PS Chines, SM Keinanen-Kiukaanniemi, TE Saaristo, S Edkins, PW Franks, G Hallmans, D Shungin, AD Morris, CN Palmer, R Erbel, S Moebus, MM Nöthen, S Pechlivanis, K Hveem, N Narisu, A Hamsten, SE Humphries, RJ Strawbridge, E Tremoli, H Grallert, B Thorand, T Illig, W Koenig, M Müller-Nurasyid, A Peters, BO Boehm, ME Kleber, W März, BR Winkelmann, J Kuusisto, M Laakso, D Arveiler, G Cesana, K Kuulasmaa, J Virtamo, JW Yarnell, D Kuh, A Wong, L Lind, U de Faire, B Gigante, PK Magnusson, NL Pedersen, G Dedoussis, M Dimitriou, G Kolovou, S Kanoni, K Stirrups, LL Bonnycastle, I Njølstad, T Wilsgaard, A Ganna, E Rehnberg, A Hingorani, M Kivimaki, M Kumari, TL Assimes, I Barroso, M Boehnke, IB Borecki, P Deloukas, CS Fox, T Frayling, LC Groop, T Haritunians, D Hunter, E Ingelsson, R Kaplan, KL Mohlke, JR O'Connell, D Schlessinger, DP Strachan, K Stefansson, CM van Duijn, GR Abecasis, MI McCarthy, JN Hirschhorn, L Qi, RJ Loos, CM Lindgren, KE North, IM Heid
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Asthma. The EFO term asthma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Barreto-Luis, M Pino-Yanes, A Corrales, P Campo, A Callero, M Acosta-Herrera, J Cumplido, SF Ma, J Martinez-Tadeo, J Villar, JG Garcia, T Carrillo, Á Carracedo, M Blanca, C Flores
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Liver enzyme levels (aspartate transaminase). The EFO term aspartate aminotransferase measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
TJ Park, JY Hwang, MJ Go, HJ Lee, HB Jang, Y Choi, JH Kang, KH Park, MG Choi, J Song, BJ Kim, JY Lee
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Liver enzyme levels (alanine transaminase). The EFO term serum alanine aminotransferase measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
TJ Park, JY Hwang, MJ Go, HJ Lee, HB Jang, Y Choi, JH Kang, KH Park, MG Choi, J Song, BJ Kim, JY Lee
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
The dataset used in this study (Bulk RNA-Seq) was previously published and can be found at NCBI GEO (GSE182321), this analysis was conducted by GEO2R to compare control and OUD samples, only top differentially expressed genes are reported. To understand mechanisms and identify potential targets for intervention in the current crisis of opioid use disorder (OUD), postmortem brains represent an under-utilized resource. To refine previously reported gene signatures of neurobiological alterations in OUD from the dorsolateral prefrontal cortex (Brodmann Area 9, BA9), we explored the role of microRNAs (miRNA) as powerful epigenetic regulators of gene function.
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
Genes associated with Homo sapiens that interact with the MeSH term 'Valproic Acid' (D014635). Incorporates data from 1238 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Oryzias latipes that interact with the MeSH term 'bisphenol A' (C006780). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Physiology of the human and animal body, male or female, in the processes and characteristics of REPRODUCTION and the URINARY TRACT.
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The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
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Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Generated by gene2mesh v. 1.1.1
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Generated by gene2mesh v. 1.1.1
The processes, properties and biological objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.
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Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome.
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