This gene set represents host genes that are required for SARS-CoV-2 infection. The genes were identified by a CRISPR screen in alveolar basal epithelial carcinoma cells. This set represents the top 100 scoring genes at a low multiplicity of infection, moi 0.01. Gene symbols of ranked genes in supplemental table 1 were converted to HGNC identifiers. Symbols that could not be unambiguously converted were omitted from the set.
Authors:
Zharko Daniloski, Tristan X Jordan, Hans-Hermann Wessels, Daisy A Hoagland, Silva Kasela, Mateusz Legut, Silas Maniatis, Eleni P Mimitou, Lu Lu, Evan Geller, Oded Danziger, Brad R Rosenberg, Hemali Phatnani, Peter Smibert, Tuuli Lappalainen, Benjamin R tenOever, Neville E Sanjana
This gene set represents host genes that are required for SARS-CoV-2 infection. The genes were identified by a CRISPR screen in alveolar basal epithelial carcinoma cells and necessity was confirmed using other methods. This set represents the top 100 scoring genes at a high multiplicity of infection, moi 0.3. Gene symbols of ranked genes in supplemental table 1 were converted to HGNC identifiers. Symbols that could not be unambiguously converted were omitted from the set.
Authors:
Zharko Daniloski, Tristan X Jordan, Hans-Hermann Wessels, Daisy A Hoagland, Silva Kasela, Mateusz Legut, Silas Maniatis, Eleni P Mimitou, Lu Lu, Evan Geller, Oded Danziger, Brad R Rosenberg, Hemali Phatnani, Peter Smibert, Tuuli Lappalainen, Benjamin R tenOever, Neville E Sanjana
This set represents genes that the authors identified through a literature search as being important in the entry or pathogenesis of human coronavirus infection. Genes were listed in figure 2B and gene symbols were converted to HGNC identifiers.
Authors:
Manoj Kumar Singh, Ahmed Mobeen, Amit Chandra, Sweta Joshi, Srinivasan Ramachandran
This set represents genes that are are co-expressed among COVID-19 infected lungs, leukemia, psoriasis, pulmonary arterial hypertension and type II diabetes liver. The reported gene symbols were converted to HGNC identifiers.
Authors:
Manoj Kumar Singh, Ahmed Mobeen, Amit Chandra, Sweta Joshi, Srinivasan Ramachandran
This set includes genes that have increased RNA expression in platelets of non-ICU patients with COVID-19 disease versus healthy donors. COVID-19 is the disease caused by SARS-CoV2 infection. Genes were selected for an adjusted p-value <0.05 and a log2fold-change >1.0. Genes were converted to HGNC identifiers. Those that could not be unambiguously converted were omitted from the set. Values represent log2fold change.
Authors:
Bhanu Kanth Manne, Frederik Denorme, Elizabeth A Middleton, Irina Portier, Jesse W Rowley, Chris Stubben, Aaron C Petrey, Neal D Tolley, Li Guo, Mark Cody, Andrew S Weyrich, Christian C Yost, Matthew T Rondina, Robert A Campbell
This set includes genes that have decreased RNA expression in platelets of nonICU patients with COVID-19 disease versus healthy donors. COVID-19 is the disease caused by SARS-CoV2 infection. Genes were selected for an adjusted p-value <0.05 and a log2fold-change >1.0. Genes were converted to HGNC identifiers. Those that could not be unambiguously converted were omitted from the set. Values represent log2fold change.
Authors:
Bhanu Kanth Manne, Frederik Denorme, Elizabeth A Middleton, Irina Portier, Jesse W Rowley, Chris Stubben, Aaron C Petrey, Neal D Tolley, Li Guo, Mark Cody, Andrew S Weyrich, Christian C Yost, Matthew T Rondina, Robert A Campbell
This set includes genes that have increased RNA expression in platelets of ICU patients with COVID-19 disease versus healthy donors. COVID-19 is the disease caused by SARS-CoV2 infection. Genes were selected for an adjusted p-value <0.05 and a log2fold-change >1.0. Genes were converted to HGNC identifiers. Those that could not be unambiguously converted were omitted from the set. Values are log2fold change.
Authors:
Bhanu Kanth Manne, Frederik Denorme, Elizabeth A Middleton, Irina Portier, Jesse W Rowley, Chris Stubben, Aaron C Petrey, Neal D Tolley, Li Guo, Mark Cody, Andrew S Weyrich, Christian C Yost, Matthew T Rondina, Robert A Campbell
This set includes genes that have decreased RNA expression in platelets of ICU patients with COVID-19 disease versus healthy donors. COVID-19 is the disease caused by SARS-CoV2 infection. Genes were selected for an adjusted p-value <0.05 and a log2fold-change >1.0. Genes were converted to HGNC identifiers. Those that could not be unambiguously converted were omitted from the set. Values represent log2fold change.
Authors:
Bhanu Kanth Manne, Frederik Denorme, Elizabeth A Middleton, Irina Portier, Jesse W Rowley, Chris Stubben, Aaron C Petrey, Neal D Tolley, Li Guo, Mark Cody, Andrew S Weyrich, Christian C Yost, Matthew T Rondina, Robert A Campbell
This set includes genes that have decreased RNA expression in platelets of patients with COVID-19 disease versus healthy donors. COVID-19 is the disease caused by SARS-CoV2 infection. Genes were selected for an adjusted p-value <0.05 and a log2fold-change >1.0. Genes were converted to HGNC identifiers. Those that could not be unambiguously converted were omitted from the set. Values represent log2fold change.
Authors:
Bhanu Kanth Manne, Frederik Denorme, Elizabeth A Middleton, Irina Portier, Jesse W Rowley, Chris Stubben, Aaron C Petrey, Neal D Tolley, Li Guo, Mark Cody, Andrew S Weyrich, Christian C Yost, Matthew T Rondina, Robert A Campbell
This set includes genes that have increased RNA expression in platelets of patients with COVID-19 disease versus healthy donors. COVID-19 is the disease caused by SARS-CoV2 infection. Genes were selected for an adjusted p-value <0.05 and a log2fold-change >1.0. Genes were converted to HGNC identifiers. Those that could not be unambiguously converted were omitted from the set. Values represent log2fold change.
Authors:
Bhanu Kanth Manne, Frederik Denorme, Elizabeth A Middleton, Irina Portier, Jesse W Rowley, Chris Stubben, Aaron C Petrey, Neal D Tolley, Li Guo, Mark Cody, Andrew S Weyrich, Christian C Yost, Matthew T Rondina, Robert A Campbell
Striatum Gene Expression Correlates for NEPVCOUNT45 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The NEPVCOUNT45 measures Novel environment rears 30-45 min in the periphery under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for NEPVCOUNT45 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The NEPVCOUNT45 measures Novel environment rears 30-45 min in the periphery under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for NEPVCOUNT60 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The NEPVCOUNT60 measures Novel environment rears 45-60 min in the periphery under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for SVCOUNT45 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The SVCOUNT45 measures Open Field Rears 30-45 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for SVCOUNT60 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The SVCOUNT60 measures Open Field Rears 45-60 min post saline under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for TNOVEL_VCOUNT_1 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The TNOVEL_VCOUNT_1 measures Novel Open Field - TOTAL rears in the center + periphery under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for HAND_6HOURS measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The HAND_6HOURS measures Handling induced convulsions 6 hrs after ethanol under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for HIC_SCORE measured in BXD RI Females & Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The HIC_SCORE measures Handling induced convulsion score under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for NOVEL_VCOUNT_1 measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The NOVEL_VCOUNT_1 measures Open Field Inovel TOTAL rears in the center under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Cerebellum Gene Expression Correlates for SPD_TIMEDOWEL30SEC measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The SPD_TIMEDOWEL30SEC measures Dowel Test - Time 30 Sec under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Genes associated with Homo sapiens that interact with the MeSH term '5-dihydrocortisone' (C045993). Incorporates data from 1538 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term '(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine' (C516138). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Copper Sulfate' (D019327). Incorporates data from 72 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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