Publication Details

Genetics of ethanol-induced locomotor activation: detection of QTLs in a C57BL/6J x DBA/2J F2 intercross.

Authors:Hitzemann R, Cipp L, Demarest K, Mahjubi E, McCaughran J Jr
Title:Genetics of ethanol-induced locomotor activation: detection of QTLs in a C57BL/6J x DBA/2J F2 intercross.
Journal:Mammalian genome : official journal of the International Mammalian Genome Society Dec 1998 , Vol 9 , pp. 956-62
Abstract:Moderate doses of ethanol (1-2 g/kg) markedly increase locomotor activity in some inbred mouse strains, for example, the DBA/2J (D2), but have relatively little effect in other strains, for example, the C57BL/6J (B6). In the present study, we conducted a genome-wide search in a B6D2 F2 intercross (N = 925) for quantitative trait loci (QTLs) associated with the locomotor response. A QTL with a LOD score of 8.4 was detected on Chromosome (Chr) 2; this QTL accounted for 11.4% of the phenotypic variance and approximately 30% of the genetic variance. The QTL on Chr 2 is in the same general region as QTLs previously described for ethanol preference/consumption (Rodriguez et al. Alcohol Clin Exp Res 19, 367, 1995; Melo et al. Nat Genet 13, 147, 1996; Phillips et al. Mamm Genome, in press), acute ethanol withdrawal (Buck et al. J. Neurosci 17, 3946, 1997) and nitrous oxide withdrawal severity (Belknap et al. Behav Genet 23, 213, 1993). A logical candidate gene in the region of interest is the enzyme which synthesizes GABA, glutamic acid decarboxylase 1 (GadI).   PUBMED: 9880659
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D005680: gamma-Aminobutyric Acid (Publication, NCBO Annotator)
  • D005968: Glutamate Decarboxylase (Publication, NCBO Annotator)
  • D008126: Lod Score (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D009609: Nitrous Oxide (Publication, NCBO Annotator)
  • D000431: Ethanol (Publication, NCBO Annotator)
  • D009043: Motor Activity (Publication, NCBO Annotator)
  • MP:0001987: alcohol preference (Publication, NCBO Annotator)
  • D018698: Glutamic Acid (Publication, NCBO Annotator)
  • D005823: Genetics (Publication, NCBO Annotator)
  • D008815: Mice, Inbred Strains (Publication, NCBO Annotator)

2 GeneSets from this Publication:


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Expand Tier II Mouse 613 Genes GS84132: ethanol induced locomotor activity (Published QTL, Chr 2)
Expand Tier I Mouse 540 Genes GS135824: ethanol induced locomotor activity (Etohila, Published QTL Chr 2)