Publication Details

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.

Authors:Berrettini WH, Ferraro TN, Alexander RC, Buchberg AM, Vogel WH
Title:Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains.
Journal:Nature genetics May 1994 , Vol 7 , pp. 54-8
Abstract:Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.   PUBMED: 8075641
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D009020: Morphine (Publication, NCBO Annotator)
  • D018895: Microsatellite Repeats (Publication, NCBO Annotator)
  • D008815: Mice, Inbred Strains (Publication, NCBO Annotator)
  • D008722: Methods (Publication, NCBO Annotator)

2 GeneSets from this Publication:


Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 378 Genes GS84115: morphine preference (Published QTL, Chr 1)
Expand Tier II Mouse 381 Genes GS84238: morphine preference (Published QTL, Chr 10)