Publication Details

Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses.

Authors:Wang J, Yuan W, Li MD
Title:Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses.
Journal:Molecular neurobiology Dec 2011 , Vol 44 , pp. 269-86
Abstract:Drug addiction is a chronic neuronal disease. In recent years, proteomics technology has been widely used to assess the protein expression in the brain tissues of both animals and humans exposed to addictive drugs. Through this approach, a large number of proteins potentially involved in the etiology of drug addictions have been identified, which provide a valuable resource to study protein function, biochemical pathways, and networks related to the molecular mechanisms underlying drug dependence. In this article, we summarize the recent application of proteomics to profiling protein expression patterns in animal or human brain tissues after the administration of alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine/heroin/butorphanol, or nicotine. From available reports, we compiled a list of 497 proteins associated with exposure to one or more addictive drugs, with 160 being related to exposure to at least two abused drugs. A number of biochemical pathways and biological processes appear to be enriched among these proteins, including synaptic transmission and signaling pathways related to neuronal functions. The data included in this work provide a summary and extension of the proteomics studies on drug addiction. Furthermore, the proteins and biological processes highlighted here may provide valuable insight into the cellular activities and biological processes in neurons in the development of drug addiction.   PUBMED: 21922273
Ontological Annotations:
  • D011506: Proteins (Publication, NCBO Annotator)
  • D006801: Humans (Publication, NCBO Annotator)
  • D009474: Neurons (Publication, NCBO Annotator)
  • GO:0023052: signaling (Publication, NCBO Annotator)
  • D013672: Technology (Publication, NCBO Annotator)
  • D009538: Nicotine (Publication, NCBO Annotator)
  • D016454: Review (Publication, NCBO Annotator)
  • D009934: Organization and Administration (Publication, NCBO Annotator)
  • D002188: Cannabis (Publication, NCBO Annotator)
  • D014937: Work (Publication, NCBO Annotator)
  • D002077: Butorphanol (Publication, NCBO Annotator)
  • D000818: Animals (Publication, NCBO Annotator)
  • D004364: Pharmaceutical Preparations (Publication, NCBO Annotator)
  • D001921: Brain (Publication, NCBO Annotator)
  • D009435: Synaptic Transmission (Publication, NCBO Annotator)
  • MP:0002555: addiction (Publication, NCBO Annotator)
  • D003932: Heroin (Publication, NCBO Annotator)
  • GO:0007268: synaptic transmission (Publication, NCBO Annotator)
  • D040901: Proteomics (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D008694: Methamphetamine (Publication, NCBO Annotator)
  • D000661: Amphetamine (Publication, NCBO Annotator)
  • D058028: Research Report (Publication, NCBO Annotator)
  • D055694: Biological Processes (Publication, NCBO Annotator)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator)
  • D003042: Cocaine (Publication, NCBO Annotator)
  • D009020: Morphine (Publication, NCBO Annotator)
  • D014024: Tissues (Publication, NCBO Annotator)
  • D013287: Street Drugs (Publication, NCBO Annotator)

1 GeneSets from this Publication:


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Expand Tier I Human 173 Genes GS128223: Proteins found to be modified by at least two drugs of abuse