Publication Details

Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.

Authors:Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ
Title:Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.
Journal:Annals of the New York Academy of Sciences Feb 2010 , Vol 1187 , pp. 184-207
Abstract:Addiction to opiates and illicit use of psychostimulants is a chronic, relapsing brain disease that, if left untreated, can cause major medical, social, and economic problems. This article reviews recent progress in studies of association of gene variants with vulnerability to develop opiate and cocaine addictions, focusing primarily on genes of the opioid and monoaminergic systems. In addition, we provide the first evidence of a cis-acting polymorphism and a functional haplotype in the PDYN gene, of significantly higher DNA methylation rate of the OPRM1 gene in the lymphocytes of heroin addicts, and significant differences in genotype frequencies of three single-nucleotide polymorphisms of the P-glycoprotein gene (ABCB1) between \"higher\" and \"lower\" methadone doses in methadone-maintained patients. In genomewide and multigene association studies, we found association of several new genes and new variants of known genes with heroin addiction. Finally, we describe the development and application of a novel technique: molecular haplotyping for studies in genetics of drug addiction.   PUBMED: 20201854
Ontological Annotations:
  • D001927: Brain Diseases (Publication, NCBO Annotator)
  • D006801: Humans (PubMed MeSH Annotations)
  • D044127: Epigenesis, Genetic (PubMed MeSH Annotations)
  • D011498: Protein Precursors (PubMed MeSH Annotations)
  • GO:0006306: DNA methylation (Publication, NCBO Annotator)
  • D044103: Receptor, Melanocortin, Type 2 (PubMed MeSH Annotations)
  • D002394: Catechol O-Methyltransferase (PubMed MeSH Annotations)
  • D019175: DNA Methylation (Publication, NCBO Annotator)
  • D010361: Patients (Publication, NCBO Annotator)
  • D001921: Brain (Publication, NCBO Annotator)
  • D004247: DNA (Publication, NCBO Annotator)
  • MP:0002555: addiction (Publication, NCBO Annotator)
  • D044302: Receptor, Serotonin, 5-HT1B (PubMed MeSH Annotations)
  • D003932: Heroin (Publication, NCBO Annotator)
  • D019970: Cocaine-Related Disorders (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D004745: Enkephalins (PubMed MeSH Annotations)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D017473: Receptors, Opioid, kappa (PubMed MeSH Annotations)
  • D010597: Pharmacogenetics (PubMed MeSH Annotations)
  • D001244: Association (Publication, NCBO Annotator)
  • D014365: Tryptophan Hydroxylase (PubMed MeSH Annotations)
  • D008691: Methadone (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D020168: P-Glycoprotein (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator)
  • D008214: Lymphocytes (Publication, NCBO Annotator)
  • D003042: Cocaine (Publication, NCBO Annotator)
  • D017450: Receptors, Opioid, mu (PubMed MeSH Annotations)
  • D014644: Genetic Variation (PubMed MeSH Annotations)
  • D005823: Genetics (Publication, NCBO Annotator)
  • D055106: Genome-Wide Association Study (PubMed MeSH Annotations)
  • D008745: Methylation (Publication, NCBO Annotator)
  • D006239: Haplotypes (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D005838: Genotype (Publication, NCBO Annotator)
  • D013812: Therapeutics (Publication, NCBO Annotator)
  • D011110: Polymorphism, Genetic (Publication, NCBO Annotator)
  • D009293: Opioid-Related Disorders (PubMed MeSH Annotations)
  • GO:0032259: methylation (Publication, NCBO Annotator)
  • D006556: Heroin Dependence (Publication, NCBO Annotator)

1 GeneSets from this Publication:

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Expand Tier I Mouse 17 Genes GS87661: Genetic Markers for Opiate and cocaine addiction