Publication Details

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.

Authors:Maze I, Covington HE 3rd, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ
Title:Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Journal:Science (New York, N.Y.) Jan 2010 , Vol 327 , pp. 213-6
Abstract:Cocaine-induced alterations in gene expression cause changes in neuronal morphology and behavior that may underlie cocaine addiction. In mice, we identified an essential role for histone 3 lysine 9 (H3K9) dimethylation and the lysine dimethyltransferase G9a in cocaine-induced structural and behavioral plasticity. Repeated cocaine administration reduced global levels of H3K9 dimethylation in the nucleus accumbens. This reduction in histone methylation was mediated through the repression of G9a in this brain region, which was regulated by the cocaine-induced transcription factor DeltaFosB. Using conditional mutagenesis and viral-mediated gene transfer, we found that G9a down-regulation increased the dendritic spine plasticity of nucleus accumbens neurons and enhanced the preference for cocaine, thereby establishing a crucial role for histone methylation in the long-term actions of cocaine.   PUBMED: 20056891
Ontological Annotations:
  • D009714: Nucleus Accumbens (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D001927: Brain Diseases (Publication, NCBO Annotator)
  • D008239: Lysine (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • GO:0016571: histone methylation (Publication, NCBO Annotator)
  • D020411: Oligonucleotide Array Sequence Analysis (PubMed MeSH Annotations)
  • GO:0043197: dendritic spine (Publication, NCBO Annotator)
  • GO:0007610: behavior (Publication, NCBO Annotator)
  • D000818: Animals (PubMed MeSH Annotations)
  • D016296: Mutagenesis (Publication, NCBO Annotator)
  • D008810: Mice, Inbred C57BL (PubMed MeSH Annotations)
  • D012201: Reward (PubMed MeSH Annotations)
  • D005786: Gene Expression Regulation (PubMed MeSH Annotations)
  • MP:0002555: addiction (Publication, NCBO Annotator)
  • D001519: Behavior (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D013131: Spine (Publication, NCBO Annotator)
  • D049229: Dendritic Spines (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D008745: Methylation (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D016760: Proto-Oncogene Proteins c-fos (PubMed MeSH Annotations)
  • D006657: Histones (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • GO:0005634: nucleus (Publication, NCBO Annotator)
  • D003042: Cocaine (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator)
  • D004794: Enzyme Repression (PubMed MeSH Annotations)
  • D001522: Behavior, Animal (PubMed MeSH Annotations)
  • D009473: Neuronal Plasticity (PubMed MeSH Annotations)
  • D012646: Self Administration (PubMed MeSH Annotations)
  • D014163: Transfer (Psychology) (Publication, NCBO Annotator)
  • D051379: Mice (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D009474: Neurons (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • GO:0010467: gene expression (Publication, NCBO Annotator)
  • D014157: Transcription Factors (Publication, NCBO Annotator)
  • D014158: Transcription, Genetic (PubMed MeSH Annotations)
  • D009934: Organization and Administration (Publication, NCBO Annotator)
  • GO:0032259: methylation (Publication, NCBO Annotator)
  • D015536: Down-Regulation (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D015085: 2,4,5-Trichlorophenoxyacetic Acid (Publication, NCBO Annotator)
  • D020869: Gene Expression Profiling (PubMed MeSH Annotations)
  • D001921: Brain (Publication, NCBO Annotator)
  • D012380: Role (Publication, NCBO Annotator)
  • MA:0000892: accumbens nucleus (Publication, NCBO Annotator)
  • D008780: Methyltransferases (Publication, NCBO Annotator)
  • D012094: Repression, Psychology (Publication, NCBO Annotator)
  • D019970: Cocaine-Related Disorders (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D011495: Histone-Lysine N-Methyltransferase (PubMed MeSH Annotations)
  • D002467: Cell Nucleus (Publication, NCBO Annotator)
  • D016739: Behavior, Addictive (Publication, NCBO Annotator)

8 GeneSets from this Publication:


Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier I Mouse DRG 3 Genes provisional GS86428: Table S4: Effect of G9a overexpression on genes that display increased mRNA induction in NAc following repeated cocaine. [DRG]
Expand Tier I Mouse DRG 3 Genes provisional GS86697: Table S4: Effect of G9a overexpression on genes that display increased mRNA induction in NAc following repeated cocaine. [DRG]
Expand Tier I Mouse DRG 3 Genes provisional GS86752: Table S3: Gene List: Repeated WD + Acute (217 Genes) [DRG]
Expand Tier I Mouse DRG 1 Genes provisional GS86990: Table S3: Gene List: Repeated WD + Acute (217 Genes) [DRG]
Expand Tier I Mouse DRG 1 Genes provisional GS87018: Table S3: Gene List: Repeated WD + Acute (217 Genes) [DRG]
Expand Tier I Mouse DRG 3 Genes provisional GS87568: Table S3: Gene List: Repeated WD + Acute (217 Genes) (Whole Table) [DRG]
Expand Tier I Mouse DRG 3 Genes provisional GS87571: Table S4: Effect of G9a overexpression on genes that display increased mRNA induction in NAc following repeated cocaine. (Whole Table) [DRG]
Expand Tier I Mouse DRG 3 Genes provisional GS87572: Table S4: Effect of G9a overexpression on genes that display increased mRNA induction in NAc following repeated cocaine. (Whole Table) [DRG]