Publication Details

Methamphetamine acts on subpopulations of neurons regulating sexual behavior in male rats.

Authors:Frohmader KS, Wiskerke J, Wise RA, Lehman MN, Coolen LM
Title:Methamphetamine acts on subpopulations of neurons regulating sexual behavior in male rats.
Journal:Neuroscience Mar 2010 , Vol 166 , pp. 771-84
Abstract:Methamphetamine (Meth) is a highly addictive stimulant. Meth abuse is commonly associated with the practice of sexual risk behavior and increased prevalence of Human Immunodeficiency Virus and Meth users report heightened sexual desire, arousal, and sexual pleasure. The biological basis for this drug-sex nexus is unknown. The current study demonstrates that Meth administration in male rats activates neurons in brain regions of the mesolimbic system that are involved in the regulation of sexual behavior. Specifically, Meth and mating co-activate cells in the nucleus accumbens core and shell, basolateral amygdala, and anterior cingulate cortex. These findings illustrate that in contrast to current belief drugs of abuse can activate the same cells as a natural reinforcer, that is sexual behavior, and in turn may influence compulsive seeking of this natural reward.   PUBMED: 20045448
Ontological Annotations:
  • D001927: Brain Diseases (Publication, NCBO Annotator)
  • D009714: Nucleus Accumbens (Publication, NCBO Annotator)
  • MA:0000887: amygdala (Publication, NCBO Annotator)
  • D017207: Rats, Sprague-Dawley (PubMed MeSH Annotations)
  • D006801: Humans (Publication, NCBO Annotator)
  • D057181: Pleasure (Publication, NCBO Annotator)
  • D015415: Biological Markers (PubMed MeSH Annotations)
  • D017579: Domestic Violence (Publication, NCBO Annotator)
  • D000697: Central Nervous System Stimulants (PubMed MeSH Annotations)
  • D000818: Animals (PubMed MeSH Annotations)
  • D012201: Reward (Publication, NCBO Annotator)
  • MA:0000904: cingulate cortex (Publication, NCBO Annotator)
  • D015995: Prevalence (Publication, NCBO Annotator)
  • D014780: Viruses (Publication, NCBO Annotator)
  • D000163: Acquired Immunodeficiency Syndrome (Publication, NCBO Annotator)
  • D004364: Pharmaceutical Preparations (Publication, NCBO Annotator)
  • D001143: Arousal (Publication, NCBO Annotator)
  • D008694: Methamphetamine (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D001519: Behavior (Publication, NCBO Annotator)
  • D002477: Cells (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • D014851: Wakefulness (Publication, NCBO Annotator)
  • D011214: Practice (Psychology) (Publication, NCBO Annotator)
  • D006678: HIV (Publication, NCBO Annotator)
  • D016760: Proto-Oncogene Proteins c-fos (PubMed MeSH Annotations)
  • D003913: Dextroamphetamine (PubMed MeSH Annotations)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator)
  • D008032: Limbic System (PubMed MeSH Annotations)
  • D012726: Sexual Behavior, Animal (PubMed MeSH Annotations)
  • D014930: Women (Publication, NCBO Annotator)
  • D004552: Elder Abuse (Publication, NCBO Annotator)
  • D000303: Adrenal Cortex Diseases (Publication, NCBO Annotator)
  • D012309: Risk-Taking (Publication, NCBO Annotator)
  • D013287: Street Drugs (Publication, NCBO Annotator)
  • D051381: Rats (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D010766: Phosphorylation (PubMed MeSH Annotations)
  • D009474: Neurons (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D003469: Culture (Publication, NCBO Annotator)
  • D009934: Organization and Administration (Publication, NCBO Annotator)
  • D012306: Risk (Publication, NCBO Annotator)
  • D000679: Amygdala (Publication, NCBO Annotator)
  • D017629: Gap Junctions (Publication, NCBO Annotator)
  • D010900: Pituitary Diseases (Publication, NCBO Annotator)
  • D048049: Extracellular Signal-Regulated MAP Kinases (PubMed MeSH Annotations)
  • D001921: Brain (Publication, NCBO Annotator)
  • MA:0000892: accumbens nucleus (Publication, NCBO Annotator)
  • D002467: Cell Nucleus (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D007153: Immunologic Deficiency Syndromes (Publication, NCBO Annotator)
  • D012725: Sexual Behavior (Publication, NCBO Annotator)

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