Publication Details

Genetic loci that regulate healing and regeneration in LG/J and SM/J mice.

Authors:Blankenhorn EP, Bryan G, Kossenkov AV, Clark LD, Zhang XM, Chang C, Horng W, Pletscher LS, Cheverud JM, Showe LC, Heber-Katz E
Title:Genetic loci that regulate healing and regeneration in LG/J and SM/J mice.
Journal:Mammalian genome : official journal of the International Mammalian Genome Society Nov-Dec 2009 , Vol 20 , pp. 720-33
Abstract:MRL mice display unusual healing properties. When MRL ear pinnae are hole punched, the holes close completely without scarring, with regrowth of cartilage and reappearance of both hair follicles and sebaceous glands. Studies using (MRL/lpr x C57BL/6)F(2) and backcross mice first showed that this phenomenon was genetically determined and that multiple loci contributed to this quantitative trait. The lpr mutation itself, however, was not one of them. In the present study we examined the genetic basis of healing in the Large (LG/J) mouse strain, a parent of the MRL mouse and a strain that shows the same healing phenotype. LG/J mice were crossed with Small (SM/J) mice and the F(2) population was scored for healing and their genotypes determined at more than 200 polymorphic markers. As we previously observed for MRL and (MRL x B6)F(2) mice, the wound-healing phenotype was sexually dimorphic, with female mice healing more quickly and more completely than male mice. We found quantitative trait loci (QTLs) on chromosomes (Chrs) 9, 10, 11, and 15. The heal QTLs on Chrs 11 and 15 were linked to differential healing primarily in male animals, whereas QTLs on Chrs 9 and 10 were not sexually dimorphic. A comparison of loci identified in previous crosses with those in the present report using LG/J x SM/J showed that loci on Chrs 9, 11, and 15 colocalized with those seen in previous MRL crosses, whereas the locus on Chr 10 was not seen before and is contributed by SM/J.   PUBMED: 19760323
Ontological Annotations:
  • MA:0000236: ear (Publication, NCBO Annotator)
  • D015211: Zellweger Syndrome (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D005838: Genotype (Publication, NCBO Annotator)
  • D012038: Regeneration (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D004423: Ear (Publication, NCBO Annotator)
  • D012627: Sebaceous Glands (Publication, NCBO Annotator)
  • D002921: Cicatrix (Publication, NCBO Annotator)
  • D058028: Research Report (Publication, NCBO Annotator)
  • D018859: Hair Follicle (Publication, NCBO Annotator)
  • D000818: Animals (Publication, NCBO Annotator)
  • D006197: Hair (Publication, NCBO Annotator)
  • D009154: Mutation (Publication, NCBO Annotator)
  • GO:0031099: regeneration (Publication, NCBO Annotator)
  • D010290: Parents (Publication, NCBO Annotator)
  • D002356: Cartilage (Publication, NCBO Annotator)
  • D056426: Genetic Loci (Publication, NCBO Annotator)

2 GeneSets from this Publication:

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Expand Tier II Mouse 1060 Genes GS135973: wound healing/regeneration 10 (Heal10, Published QTL Chr 11)
Expand Tier II Mouse 624 Genes GS136764: soft tissue heal 8 (Stheal8, Published QTL Chr 9)