Publication Details

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.

Authors:Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ
Title:Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.
Journal:Neuron May 2009 , Vol 62 , pp. 335-48
Abstract:Changes in gene expression contribute to the long-lasting regulation of the brain\'s reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region. The findings also provide comprehensive insight into the molecular pathways regulated by cocaine-including a new role for sirtuins (Sirt1 and Sirt2)-which are induced in the nucleus accumbens by cocaine and, in turn, dramatically enhance the behavioral effects of the drug.   PUBMED: 19447090
Ontological Annotations:
  • D009714: Nucleus Accumbens (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D047369: Chromatin Immunoprecipitation (Publication, NCBO Annotator)
  • D001927: Brain Diseases (Publication, NCBO Annotator)
  • D020411: Oligonucleotide Array Sequence Analysis (PubMed MeSH Annotations)
  • D018765: Dopamine Uptake Inhibitors (PubMed MeSH Annotations)
  • D000818: Animals (PubMed MeSH Annotations)
  • D002843: Chromatin (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D012201: Reward (Publication, NCBO Annotator)
  • D008810: Mice, Inbred C57BL (PubMed MeSH Annotations)
  • D047468: Immunoprecipitation (Publication, NCBO Annotator)
  • D025461: Feedback, Physiological (PubMed MeSH Annotations)
  • D011401: Promoter Regions, Genetic (PubMed MeSH Annotations)
  • D004364: Pharmaceutical Preparations (Publication, NCBO Annotator)
  • MA:0000892: accumbens nucleus (Publication, NCBO Annotator)
  • D001921: Brain (Publication, NCBO Annotator)
  • D012380: Role (Publication, NCBO Annotator)
  • D005786: Gene Expression Regulation (PubMed MeSH Annotations)
  • MP:0002555: addiction (Publication, NCBO Annotator)
  • D015398: Signal Transduction (PubMed MeSH Annotations)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • D002467: Cell Nucleus (Publication, NCBO Annotator)
  • D016739: Behavior, Addictive (Publication, NCBO Annotator)
  • D016760: Proto-Oncogene Proteins c-fos (PubMed MeSH Annotations)
  • D003042: Cocaine (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • GO:0005634: nucleus (Publication, NCBO Annotator)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator)
  • D037761: Sirtuins (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D046228: Microarray Analysis (Publication, NCBO Annotator)
  • D055106: Genome-Wide Association Study (PubMed MeSH Annotations)
  • GO:0000785: chromatin (Publication, NCBO Annotator)
  • D051379: Mice (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • GO:0010467: gene expression (Publication, NCBO Annotator)
  • D012054: Reinforcement (Psychology) (PubMed MeSH Annotations)
  • D014157: Transcription Factors (Publication, NCBO Annotator)
  • D009934: Organization and Administration (Publication, NCBO Annotator)
  • D017362: Cyclic AMP Response Element-Binding Protein (PubMed MeSH Annotations)

10 GeneSets from this Publication:


Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier I Mouse DRG 839 Genes provisional GS86420: Table S4: Cocaine Regulation of Dimethyl-K9 / K27 H3. [DRG]
Expand Tier I Mouse DRG 189 Genes provisional GS86604: Table S3: Cocaine Regulation of Both H3 and H4 Acetylation. acH3 up and acH4 up [DRG]
Expand Tier I Mouse DRG 867 Genes provisional GS86789: Table S1: Cocaine Regulation of H3 Acetylation. [DRG]
Expand Tier I Mouse DRG 3 Genes provisional GS86797: Table S3: Cocaine Regulation of Both H3 and H4 Acetylation. acH3 down and acH4 down [DRG]
Expand Tier I Mouse DRG 188 Genes provisional GS86916: Table S4: Cocaine Regulation of Dimethyl-K9 / K27 H3. [DRG]
Expand Tier I Mouse DRG 75 Genes provisional GS86930: Table S1: Cocaine Regulation of H3 Acetylation. [DRG]
Expand Tier I Mouse DRG 26 Genes provisional GS86963: Table S5: Cocaine Regulation of Histone Acetylation and Methylation. acH3 / acH4 up and meH3 down [DRG]
Expand Tier I Mouse DRG 613 Genes provisional GS87058: Table S2: Cocaine Regulation of H4 Acetylation. [DRG]
Expand Tier I Mouse DRG 10 Genes provisional GS87163: Table S5: Cocaine Regulation of Histone Acetylation and Methylation. acH3 / acH4 down and meH3 up [DRG]
Expand Tier I Mouse DRG 106 Genes provisional GS87186: Table S2: Cocaine Regulation of H4 Acetylation. [DRG]