Publication Details

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.

Authors:Renthal W, Maze I, Krishnan V, Covington HE 3rd, Xiao G, Kumar A, Russo SJ, Graham A, Tsankova N, Kippin TE, Kerstetter KA, Neve RL, Haggarty SJ, McKinsey TA, Bassel-Duby R, Olson EN, Nestler EJ
Title:Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Journal:Neuron Nov 2007 , Vol 56 , pp. 517-29
Abstract:Previous work has identified alterations in histone acetylation in animal models of drug addiction and depression. However, the mechanisms which integrate drugs and stress with changes in chromatin structure remain unclear. Here, we identify the activity-dependent class II histone deacetylase, HDAC5, as a central integrator of these stimuli with changes in chromatin structure and gene expression. Chronic, but not acute, exposure to cocaine or stress decreases HDAC5 function in the nucleus accumbens (NAc), a major brain reward region, which allows for increased histone acetylation and transcription of HDAC5 target genes. This regulation is behaviorally important, as loss of HDAC5 causes hypersensitive responses to chronic, not acute, cocaine or stress. These findings suggest that proper balance of histone acetylation is a crucial factor in the saliency of a given stimulus and that disruption of this balance is involved in the transition from an acute adaptive response to a chronic psychiatric illness.   PUBMED: 17988634
Ontological Annotations:
  • D009714: Nucleus Accumbens (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D001927: Brain Diseases (Publication, NCBO Annotator)
  • D015971: Gene Expression Regulation, Enzymologic (PubMed MeSH Annotations)
  • D003865: Depressive Disorder, Major (Publication, NCBO Annotator)
  • D018765: Dopamine Uptake Inhibitors (PubMed MeSH Annotations)
  • D044127: Epigenesis, Genetic (PubMed MeSH Annotations)
  • D004195: Disease Models, Animal (PubMed MeSH Annotations)
  • D000818: Animals (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D002843: Chromatin (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D012201: Reward (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D008810: Mice, Inbred C57BL (PubMed MeSH Annotations)
  • GO:0016573: histone acetylation (Publication, NCBO Annotator)
  • D004644: Emotions (PubMed MeSH Annotations)
  • D004364: Pharmaceutical Preparations (Publication, NCBO Annotator)
  • MP:0002555: addiction (Publication, NCBO Annotator)
  • D013315: Stress, Psychological (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D002908: Chronic Disease (PubMed MeSH Annotations)
  • D002467: Cell Nucleus (Publication, NCBO Annotator)
  • D006655: Histone Deacetylases (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D016739: Behavior, Addictive (Publication, NCBO Annotator)
  • D003866: Depressive Disorder (Publication, NCBO Annotator)
  • D006657: Histones (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • GO:0005634: nucleus (Publication, NCBO Annotator)
  • D003042: Cocaine (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D001523: Mental Disorders (Publication, NCBO Annotator)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator)
  • D000222: Adaptation, Physiological (PubMed MeSH Annotations)
  • GO:0000785: chromatin (Publication, NCBO Annotator)
  • D003863: Depression (Publication, NCBO Annotator)
  • D000107: Acetylation (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D051379: Mice (PubMed MeSH Annotations)
  • D023421: Models, Animal (Publication, NCBO Annotator)
  • GO:0010467: gene expression (Publication, NCBO Annotator)
  • D014937: Work (Publication, NCBO Annotator)
  • D000890: Anti-Infective Agents (Publication, NCBO Annotator)
  • D001921: Brain (Publication, NCBO Annotator)
  • MA:0000892: accumbens nucleus (Publication, NCBO Annotator)
  • D000275: Adjustment Disorders (Publication, NCBO Annotator)
  • D019970: Cocaine-Related Disorders (PubMed MeSH Annotations)
  • D002965: Classification (Publication, NCBO Annotator)

8 GeneSets from this Publication:


Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier I Mouse DRG 439 Genes provisional GS86502: Table S3: List of Cocaine-Treated HDAC5 KO vs. Saline-Treated HDAC5 KO Significantly Regulated Genes. [DRG]
Expand Tier I Mouse DRG 583 Genes GS86746: Table S5: List of Cocaine-Treated WT vs. Saline-Treated WT Significantly Regulated Genes. [DRG]
Expand Tier I Mouse DRG 514 Genes provisional GS87011: Table S2: List of Cocaine-Treated HDAC5 KO vs. Cocaine-Treated WT Significantly Regulated Genes. [DRG]
Expand Tier I Mouse DRG 355 Genes provisional GS87019: Table S5: List of Cocaine-Treated WT vs. Saline-Treated WT Significantly Regulated Genes. [DRG]
Expand Tier I Mouse DRG 394 Genes provisional GS87041: Table S3: List of Cocaine-Treated HDAC5 KO vs. Saline-Treated HDAC5 KO Significantly Regulated Genes. [DRG]
Expand Tier I Mouse DRG 315 Genes provisional GS87065: Table S4: List of Saline-Treated HDAC5 KO vs. Saline-Treated WT Significantly Regulated Genes. [DRG]
Expand Tier I Mouse DRG 449 Genes provisional GS87096: Table S2: List of Cocaine-Treated HDAC5 KO vs. Cocaine-Treated WT Significantly Regulated Genes. [DRG]
Expand Tier I Mouse DRG 516 Genes provisional GS87101: Table S4: List of Saline-Treated HDAC5 KO vs. Saline-Treated WT Significantly Regulated Genes. [DRG]