Publication Details

New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.

Authors:Fujiwara K, Igarashi J, Irahara N, Kimura M, Nagase H
Title:New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.
Journal:BMC genetics Jun 2007 , Vol 8 , pp. 39
Abstract:A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen Skts loci for skin tumour susceptibility have been mapped so far by using the two-stage skin carcinogenesis model [induced by 7.12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)]. A few responsible genes have been identified using wild-derived dominant resistant Mus spretus mice, and one has been confirmed as a low penetrance cancer susceptibility gene in a variety of human cancers.In the present study, we found that wild-derived PWK mice developed no tumour by treatment with the two-stage skin carcinogenesis protocol. This phenotype is dominant resistant when crossed with the highly susceptible strain FVB. By analyzing the F1 backcross generation between PWK and FVB, we found empirical evidence of significant linkage at the new loci Skts-fp1 on chromosome 4 and suggestive linkage on chromosomes 1, 3, 11, 12 and 14 for skin tumour susceptibility. Skts-fp1 includes the Skts7 interval, which was previously mapped by a Mus spretus and NIH backcross. We also observed suggestive linkage on chromosomes 1 and 2 in the female population only, while suggestive linkage on chromosomes 14 and 15 only was observed in the male population. A significant genetic interaction was seen between markers of D11Mit339 and D16Mit14.Analysis of this new cross may facilitate the identification of genes responsible for mouse skin cancer susceptibility and may reveal their biological interactions.   PUBMED: 17598916
Ontological Annotations:
  • D009369: Neoplasms (Publication, NCBO Annotator)
  • D006801: Humans (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D007062: Identification (Psychology) (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D012867: Skin (Publication, NCBO Annotator)
  • D009316: National Institutes of Health (U.S.) (Publication, NCBO Annotator)
  • D013812: Therapeutics (Publication, NCBO Annotator)
  • MA:0000151: skin (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D019683: Penetrance (Publication, NCBO Annotator)
  • D002894: Chromosomes, Human, Pair 4 (Publication, NCBO Annotator)
  • D012878: Skin Neoplasms (Publication, NCBO Annotator)

2 GeneSets from this Publication:


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Expand Tier I Mouse 543 Genes GS129184: skin tumor susceptibility in FVB and PWK 1 (Skts-fp1 Published QTL Chr 4)
Expand Tier I Mouse 152 Genes GS129185: skin tumor susceptibility in FVB and PWK 3 (Skts-fp3 Published QTL Chr 16)