Publication Details

Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance.

Authors:Wang M, Zhang Z, Zhang Z, Vikis H, Yan Y, Wang Y, You M
Title:Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance.
Journal:Cancer research Mar 2007 , Vol 67 , pp. 2508-16
Abstract:Pulmonary adenoma resistance 1 (Par1) is a major genetic determinant of mouse lung adenoma resistance. Although Par1 was previously mapped to mouse chromosome 11 by conventional linkage analyses, its candidate region was broad and undefined. In our present study, we generated Par1 congenic mice using two mouse strains A/J (Par1/-) and Mus spretus (Par1/+). Analyzing these congenic mice enabled us to fine map the Par1 quantitative trait loci (QTL) into a 2.0-cM (2.2 Mb) chromosomal region between genetic marker D11Mit70 and the gene Hoxb9. We then conducted systematic candidate gene screening through nucleotide polymorphism and expression analyses. Genes showing differential lung tissue expression or carrying nonsynonymous single nucleotide polymorphisms were identified and discussed. In particular, we evaluated tumor suppressor gene Tob1 for its Par1 candidacy. Our findings have narrowed the Par1 QTL region and will greatly facilitate the identification of the major genetic determinant of mouse lung adenoma resistance.   PUBMED: 17363568
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D009369: Neoplasms (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D005819: Genetic Markers (Publication, NCBO Annotator)
  • D007062: Identification (Psychology) (Publication, NCBO Annotator)
  • D016153: Genes, Suppressor (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D008403: Mass Screening (Publication, NCBO Annotator)
  • D011110: Polymorphism, Genetic (Publication, NCBO Annotator)
  • D056726: Genetic Association Studies (Publication, NCBO Annotator)
  • D017770: Lifting (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D008168: Lung (Publication, NCBO Annotator)
  • D020641: Polymorphism, Single Nucleotide (Publication, NCBO Annotator)
  • D000236: Adenoma (Publication, NCBO Annotator)
  • MA:0000415: lung (Publication, NCBO Annotator)
  • D002880: Chromosomes, Human, Pair 11 (Publication, NCBO Annotator)
  • D020297: Mice, Congenic (Publication, NCBO Annotator)
  • D016147: Genes, Tumor Suppressor (Publication, NCBO Annotator)
  • D014024: Tissues (Publication, NCBO Annotator)

1 GeneSets from this Publication:


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Expand Tier I Mouse 1003 Genes GS136433: pulmonary adenoma susceptibility 5a (Pas5a, Published QTL Chr 11)