Publication Details

Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci.

Authors:Malmanger B, Lawler M, Coulombe S, Murray R, Cooper S, Polyakov Y, Belknap J, Hitzemann R
Title:Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci.
Journal:Mammalian genome : official journal of the International Mammalian Genome Society Dec 2006 , Vol 17 , pp. 1193-204
Abstract:We have completed whole-genome scans for quantitative trait loci (QTLs) associated with acute ethanol-induced activation in the six F(2) intercrosses that can be formed from the C57BL/6J (B6), DBA/2J (D2) , BALB/cJ (C), and LP/J (LP) inbred strains. The goal was to test the hypothesis that given the relatively simple structure of the laboratory mouse genome, the same QTLs will be detected in multiple crosses which in turn will provide support for the strategy of multiple-cross mapping (MCM). QTLs with LOD scores greater than 4 were detected on Chrs 1, 2, 3, 8, 9, 13, 14, and 16. Only for the QTL on distal Chr 1 was there convincing evidence that the same or at least a very similar QTL was detected in multiple crosses. We also mapped the Chr 2 QTL directly in heterogeneous stock (HS) animals derived from the four inbred strains. At G(19) the QTL was mapped to an approximately 3-Mbp interval and this interval was associated with a haplotype block with a largely biallelic structure: B6-L:C-D2. We conclude that mapping in HS animals not only provides significantly greater QTL resolution, at least in some cases it provides significantly more information about the QTL haplotype structure.   PUBMED: 17143586
Ontological Annotations:
  • D015211: Zellweger Syndrome (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D006040: Goals (Publication, NCBO Annotator)
  • D006239: Haplotypes (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D008126: Lod Score (Publication, NCBO Annotator)
  • D007753: Laboratories (Publication, NCBO Annotator)
  • D000818: Animals (Publication, NCBO Annotator)

4 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 465 Genes GS135234: activity response to ethanol 1 (Actre1, Published QTL Chr 1)
Expand Tier II Mouse 534 Genes GS135235: activity response to ethanol 2 (Actre2, Published QTL Chr 2)
Expand Tier II Mouse 210 Genes GS135238: activity response to ethanol 5 (Actre5, Published QTL Chr 3)
Expand Tier II Mouse 593 Genes GS135239: activity response to ethanol 6 (Actre6, Published QTL Chr 9)