Publication Details

Murine weight loss exhibits significant genetic variation during dietary restriction.

Authors:Rikke BA, Battaglia ME, Allison DB, Johnson TE
Title:Murine weight loss exhibits significant genetic variation during dietary restriction.
Journal:Physiological genomics Oct 2006 , Vol 27 , pp. 122-30
Abstract:We present genetic analyses of murine weight loss during dietary restriction (DR) for females eating 60% ad libitum (AL). We examined 5 cohorts across 81 different strains (22 strains tested twice) that included the LXS and LSXSS recombinant inbred strains, the LXS parental strains ILS and ISS, and the classical inbreds 129S6, A, BALB/c, C57BL/6, C3H, and DBA. Weight loss exhibited highly significant genetic variation, with DR body weights ranging from approximately 60 to approximately 85% of AL body weight. This variation was not explained by the strain differences in absolute food intake, feces calorie content, motor activity, or AL body fat. Heritability was 40-50%, and several provisional quantitative trait loci were mapped. This variation can be used to test whether weight loss correlates with the health benefits of DR, independently of the reduction in calories. The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction.   PUBMED: 16849633
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D001835: Body Weight (Publication, NCBO Annotator)
  • MP:0001263: weight loss (Publication, NCBO Annotator)
  • D013812: Therapeutics (Publication, NCBO Annotator)
  • D015431: Weight Loss (Publication, NCBO Annotator)
  • D005243: Feces (Publication, NCBO Annotator)
  • D009043: Motor Activity (Publication, NCBO Annotator)
  • D000273: Adipose Tissue (Publication, NCBO Annotator)
  • GO:0003774: motor activity (Publication, NCBO Annotator)
  • D005085: Exhibits as Topic (Publication, NCBO Annotator)
  • D014644: Genetic Variation (Publication, NCBO Annotator)
  • D004435: Eating (Publication, NCBO Annotator)
  • D006262: Health (Publication, NCBO Annotator)
  • D005502: Food (Publication, NCBO Annotator)
  • D007342: Insurance Benefits (Publication, NCBO Annotator)
  • MA:0002509: feces (Publication, NCBO Annotator)
  • MA:0000009: adipose tissue (Publication, NCBO Annotator)

4 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 424 Genes GS136963: weight loss response 1 (Wtlr1, Published QTL Chr 6)
Expand Tier II Mouse 469 Genes GS136964: weight loss response 2 (Wtlr2, Published QTL Chr 16)
Expand Tier II Mouse 370 Genes GS136965: weight loss response 3 (Wtlr3, Published QTL Chr 4)
Expand Tier II Mouse 730 Genes GS136966: weight loss response 4 (Wtlr4, Published QTL Chr 7)