Publication Details

Candidate genes and their regulatory elements: alcohol preference and tolerance.

Authors:Saba L, Bhave SV, Grahame N, Bice P, Lapadat R, Belknap J, Hoffman PL, Tabakoff B
Title:Candidate genes and their regulatory elements: alcohol preference and tolerance.
Journal:Mammalian genome : official journal of the International Mammalian Genome Society Jun 2006 , Vol 17 , pp. 669-88
Abstract:QTL analysis of behavioral traits and mouse brain gene expression studies were combined to identify candidate genes involved in the traits of alcohol preference and acute functional alcohol tolerance. The systematic application of normalization and statistical analysis of differential gene expression, behavioral and expression QTL location, and informatics methodologies resulted in identification of 8 candidate genes for the trait of alcohol preference and 22 candidate genes for acute functional tolerance. Pathway analysis, combined with clustering by ontology, indicated the importance of transcriptional regulation and DNA and protein binding elements in the acute functional tolerance trait, and protein kinases and intracellular signal transduction elements in the alcohol preference trait. A rudimentary search for transcription control elements that could indicate coregulation of the panels of candidate genes produced modest results, implicating SMAD-3 in the regulation of four of the eight candidate genes for alcohol preference. However, the realization of the many caveats related to transcription factor binding site analysis, and attempts to correlate between transcription factor binding and function, forestalled any definitive global analysis of transcriptional control of differentially expressed candidate genes.   PUBMED: 16783646
Ontological Annotations:
  • GO:0005488: binding (Publication, NCBO Annotator)
  • GO:0005515: protein binding (Publication, NCBO Annotator)
  • D008811: Mice, Inbred DBA (PubMed MeSH Annotations)
  • D000428: Alcohol Drinking (PubMed MeSH Annotations)
  • D007062: Identification (Psychology) (Publication, NCBO Annotator)
  • D051379: Mice (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D016000: Cluster Analysis (Publication, NCBO Annotator)
  • D004361: Drug Tolerance (PubMed MeSH Annotations)
  • D005809: Genes, Regulator (PubMed MeSH Annotations)
  • GO:0010467: gene expression (Publication, NCBO Annotator)
  • D014157: Transcription Factors (Publication, NCBO Annotator)
  • D010770: Phosphotransferases (Publication, NCBO Annotator)
  • D011485: Protein Binding (Publication, NCBO Annotator)
  • D000818: Animals (PubMed MeSH Annotations)
  • D048088: Informatics (Publication, NCBO Annotator)
  • GO:0008134: transcription factor binding (Publication, NCBO Annotator)
  • D008810: Mice, Inbred C57BL (PubMed MeSH Annotations)
  • GO:0005622: intracellular (Publication, NCBO Annotator)
  • D001921: Brain (Publication, NCBO Annotator)
  • D004247: DNA (Publication, NCBO Annotator)
  • D015398: Signal Transduction (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • GO:0009293: transduction (Publication, NCBO Annotator)
  • D001665: Binding Sites (Publication, NCBO Annotator)
  • MP:0001987: alcohol preference (Publication, NCBO Annotator)
  • D011494: Protein Kinases (Publication, NCBO Annotator)
  • D004602: Elements (Publication, NCBO Annotator)
  • GO:0007165: signal transduction (Publication, NCBO Annotator)
  • GO:0035556: intracellular signal transduction (Publication, NCBO Annotator)

5 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 79 Genes GS129076: "alcohol preference locus 1, male specific" (Alcp1 Published QTL Chr 2)
Expand Tier II Mouse 4 Genes GS129134: ethanol consumption 2 (Etohc2 Published QTL Chr 2)
Expand Tier II Mouse 313 Genes GS135314: alcohol preference 2 QTL (Ap2q, Published QTL Chr 2)
Expand Tier II Mouse 552 Genes GS135315: alcohol preference 3 QTL (Ap3q, Published QTL Chr 4)
Expand Tier II Mouse 469 Genes GS135820: ethanol consumption 1 (Etohc1, Published QTL Chr 2)