| Authors: | Willis-Owen SA, Flint J |
|---|
| Title: | The genetic basis of emotional behaviour in mice. |
|---|
| Journal: | European journal of human genetics : EJHG
Jun 2006 , Vol 14 , pp. 721-8 |
|---|
| Abstract: | The last decade has witnessed a steady expansion in the number of quantitative trait loci (QTL) mapped for complex phenotypes. However, despite this proliferation, the number of successfully cloned QTL has remained surprisingly low, and to a great extent limited to large effect loci. In this review, we follow the progress of one complex trait locus; a low magnitude moderator of murine emotionality identified some 10 years ago in a simple two-strain intercross, and successively resolved using a variety of crosses and fear-related phenotypes. These experiments have revealed a complex underlying genetic architecture, whereby genetic effects fractionate into several separable QTL with some evidence of phenotype specificity. Ultimately, we describe a method of assessing gene candidacy, and show that given sufficient access to genetic diversity and recombination, progression from QTL to gene can be achieved even for low magnitude genetic effects.
PUBMED: 16721408
|
|---|
| Ontological Annotations: |
- D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
- D051379: Mice (Publication, NCBO Annotator)
- D016454: Review (Publication, NCBO Annotator)
- GO:0007610: behavior (Publication, NCBO Annotator)
- D014644: Genetic Variation (Publication, NCBO Annotator)
- D011995: Recombination, Genetic (Publication, NCBO Annotator)
- D001108: Architecture as Topic (Publication, NCBO Annotator)
|
|---|
