Publication Details

Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice.

Authors:Yi N, Zinniel DK, Kim K, Eisen EJ, Bartolucci A, Allison DB, Pomp D
Title:Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice.
Journal:Genetical research Feb 2006 , Vol 87 , pp. 45-60
Abstract:To comprehensively investigate the genetic architecture of growth and obesity, we performed Bayesian analyses of multiple epistatic quantitative trait locus (QTL) models for body weights at five ages (12 days, 3, 6, 9 and 12 weeks) and body composition traits (weights of two fat pads and five organs) in mice produced from a cross of the F1 between M16i (selected for rapid growth rate) and CAST/Ei (wild-derived strain of small and lean mice) back to M16i. Bayesian model selection revealed a temporally regulated network of multiple QTL for body weight, involving both strong main effects and epistatic effects. No QTL had strong support for both early and late growth, although overlapping combinations of main and epistatic effects were observed at adjacent ages. Most main effects and epistatic interactions had an opposite effect on early and late growth. The contribution of epistasis was more pronounced for body weights at older ages. Body composition traits were also influenced by an interacting network of multiple QTLs. Several main and epistatic effects were shared by the body composition and body weight traits, suggesting that pleiotropy plays an important role in growth and obesity.   PUBMED: 16545150
Ontological Annotations:
  • MA:0000009: adipose tissue (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D001835: Body Weight (Publication, NCBO Annotator)
  • D006128: Growth (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D001823: Body Composition (Publication, NCBO Annotator)
  • D000273: Adipose Tissue (Publication, NCBO Annotator)
  • MP:0001261: obese (Publication, NCBO Annotator)
  • D010988: Play and Playthings (Publication, NCBO Annotator)
  • D009765: Obesity (Publication, NCBO Annotator)
  • D012380: Role (Publication, NCBO Annotator)
  • GO:0040007: growth (Publication, NCBO Annotator)
  • D001108: Architecture as Topic (Publication, NCBO Annotator)

2 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 287 Genes GS135921: growth traits 1 (Gwth1, Published QTL Chr 1)
Expand Tier II Mouse 208 Genes GS135922: growth traits 7 (Gwth7, Published QTL Chr 18)