Publication Details

Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals.

Authors:Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, Mayfield RD
Title:Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals.
Journal:Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jul 2006 , Vol 31 , pp. 1574-82
Abstract:Alcohol dependence is characterized by tolerance, physical dependence, and craving. The neuroadaptations underlying these effects of chronic alcohol abuse are likely due to altered gene expression. Previous gene expression studies using human post-mortem brain demonstrated that several gene families were altered by alcohol abuse. However, most of these changes in gene expression were small. It is not clear if gene expression profiles have sufficient power to discriminate control from alcoholic individuals and how consistent gene expression changes are when a relatively large sample size is examined. In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A partial least squares statistical procedure was applied to identify genes with altered expression levels in alcoholics. We found that genes involved in myelination, ubiquitination, apoptosis, cell adhesion, neurogenesis, and neural disease showed altered expression levels. Importantly, genes involved in neurodegenerative diseases such as Alzheimer\'s disease were significantly altered suggesting a link between alcoholism and other neurodegenerative conditions. A total of 27 genes identified in this study were previously shown to be changed by alcohol abuse in previous studies of human post-mortem brain. These results revealed a consistent re-programming of gene expression in alcohol abusers that reliably discriminates alcoholic from non-alcoholic individuals.   PUBMED: 16292326
Ontological Annotations:
  • D001927: Brain Diseases (Publication, NCBO Annotator)
  • D015984: Causality (Publication, NCBO Annotator)
  • D006801: Humans (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D019636: Neurodegenerative Diseases (Publication, NCBO Annotator)
  • D020411: Oligonucleotide Array Sequence Analysis (PubMed MeSH Annotations)
  • D002448: Cell Adhesion (Publication, NCBO Annotator)
  • GO:0042552: myelination (Publication, NCBO Annotator)
  • D055495: Neurogenesis (Publication, NCBO Annotator)
  • D017579: Domestic Violence (Publication, NCBO Annotator)
  • D000368: Aged (PubMed MeSH Annotations)
  • D017209: Apoptosis (Publication, NCBO Annotator)
  • D000369: Aged, 80 and over (PubMed MeSH Annotations)
  • GO:0022008: neurogenesis (Publication, NCBO Annotator)
  • D000544: Alzheimer Disease (Publication, NCBO Annotator)
  • D005190: Family (Publication, NCBO Annotator)
  • D005786: Gene Expression Regulation (PubMed MeSH Annotations)
  • D002477: Cells (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D000438: Alcohols (Publication, NCBO Annotator)
  • D011180: Postmortem Changes (PubMed MeSH Annotations)
  • D000431: Ethanol (Publication, NCBO Annotator)
  • D016022: Case-Control Studies (PubMed MeSH Annotations)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator)
  • D046228: Microarray Analysis (Publication, NCBO Annotator)
  • D004552: Elder Abuse (Publication, NCBO Annotator)
  • D008722: Methods (Publication, NCBO Annotator)
  • D000303: Adrenal Cortex Diseases (Publication, NCBO Annotator)
  • D013618: Tachyphylaxis (Publication, NCBO Annotator)
  • D016018: Least-Squares Analysis (Publication, NCBO Annotator)
  • D000437: Alcoholism (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • MA:0000905: frontal cortex (Publication, NCBO Annotator)
  • GO:0007155: cell adhesion (Publication, NCBO Annotator)
  • D012202: Reye Syndrome (Publication, NCBO Annotator)
  • D018401: Sample Size (Publication, NCBO Annotator)
  • D020774: Pick Disease of the Brain (Publication, NCBO Annotator)
  • GO:0010467: gene expression (Publication, NCBO Annotator)
  • D011209: Power (Psychology) (Publication, NCBO Annotator)
  • D057229: Alcoholics (Publication, NCBO Annotator)
  • D020869: Gene Expression Profiling (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D001921: Brain (Publication, NCBO Annotator)
  • D000328: Adult (PubMed MeSH Annotations)
  • D000267: Tissue Adhesions (Publication, NCBO Annotator)
  • D054875: Ubiquitination (Publication, NCBO Annotator)
  • GO:0005623: cell (Publication, NCBO Annotator)
  • D008875: Middle Aged (PubMed MeSH Annotations)
  • D005625: Frontal Lobe (PubMed MeSH Annotations)
  • D014930: Women (Publication, NCBO Annotator)
  • D012333: RNA, Messenger (PubMed MeSH Annotations)

4 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier III Human 368 Genes GS37108: Mayfield Human Alcoholism
Expand Tier I Human DRG 2 Genes provisional GS86817: Table S6: Full list of identified genes (531 genes). Green indicates down-regulation and red for up-regulation in alcoholic group. [DRG]
Expand Tier I Human DRG 1 Genes GS86868: Table S6: Full list of identified genes (531 genes). Green indicates down-regulation and red for up-regulation in alcoholic group. [DRG]
Expand Tier I Human DRG 219 Genes GS87330: Table S7: List of genes in each functional group. (Whole Table) [DRG]