Publication Details

Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction.

Authors:Kreek MJ, Nielsen DA, Butelman ER, LaForge KS
Title:Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction.
Journal:Nature neuroscience Nov 2005 , Vol 8 , pp. 1450-7
Abstract:Genetic variation may partially underlie complex personality and physiological traits--such as impulsivity, risk taking and stress responsivity--as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases.   PUBMED: 16251987
Ontological Annotations:
  • D006801: Humans (PubMed MeSH Annotations)
  • D012306: Risk (Publication, NCBO Annotator)
  • D000818: Animals (PubMed MeSH Annotations)
  • D013312: Stress, Physiological (PubMed MeSH Annotations)
  • D015897: Comorbidity (PubMed MeSH Annotations)
  • D000339: Affect (Publication, NCBO Annotator)
  • MP:0002555: addiction (Publication, NCBO Annotator)
  • D007175: Impulsive Behavior (PubMed MeSH Annotations)
  • D008954: Models, Biological (PubMed MeSH Annotations)
  • D012309: Risk-Taking (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D010551: Personality (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D014644: Genetic Variation (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D012008: Recurrence (Publication, NCBO Annotator)

1 GeneSets from this Publication:


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Expand Tier III Human 28 Genes GS1132: Addiction candidate genes