Publication Details

Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.

Authors:Darakhshan F, Badie C, Moody J, Coster M, Finnon R, Finnon P, Edwards AA, Szluinska M, Skidmore CJ, Yoshida K, Ullrich R, Cox R, Bouffler SD
Title:Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.
Journal:Carcinogenesis Feb 2006 , Vol 27 , pp. 311-8
Abstract:The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute myeloid leukaemia (AML) in the mouse based on chromosomal radiosensitivity has been developed and validated. This assay was applied to the mapping of radiation-induced AML risk modifier loci by association with microsatellite markers. A region on chromosome (chr) 18 with strong association is identified and confirmed by backcross analysis. Additional loci on chrs 8 and 13 show significant association. A key candidate gene Rbbp8 on chr18 is identified. Rbbp8 is shown to be upregulated in response to X-irradiation in the AML sensitive CBA strain but not AML resistant C57BL/6 strain. This study demonstrates the strength of utilizing surrogate endpoints of cancer susceptibility in the mapping of mouse loci and identifies additional loci that may affect radiation cancer risk.   PUBMED: 16093251
Ontological Annotations:
  • D015415: Biological Markers (Publication, NCBO Annotator)
  • D015211: Zellweger Syndrome (Publication, NCBO Annotator)
  • D009369: Neoplasms (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D011827: Radiation (Publication, NCBO Annotator)
  • D014918: Wills (Publication, NCBO Annotator)
  • D012306: Risk (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D000339: Affect (Publication, NCBO Annotator)
  • D011836: Radiation Tolerance (Publication, NCBO Annotator)
  • D001244: Association (Publication, NCBO Annotator)
  • D018895: Microsatellite Repeats (Publication, NCBO Annotator)

4 GeneSets from this Publication:


Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier I Mouse 243 Genes GS136569: radiation induced acute myeloid leukemia 1 (Raml1, Published QTL Chr 18)
Expand Tier I Mouse 351 Genes GS136570: radiation induced acute myeloid leukemia 2 (Raml2, Published QTL Chr 3)
Expand Tier I Mouse 652 Genes GS136571: radiation induced acute myeloid leukemia 3 (Raml3, Published QTL Chr 4)
Expand Tier I Mouse 455 Genes GS136572: radiation induced acute myeloid leukemia 4 (Raml4, Published QTL Chr 8)