Publication Details

Regulation of dopaminergic transmission and cocaine reward by the Clock gene.

Authors:McClung CA, Sidiropoulou K, Vitaterna M, Takahashi JS, White FJ, Cooper DC, Nestler EJ
Title:Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
Journal:Proceedings of the National Academy of Sciences of the United States of America Jun 2005 , Vol 102 , pp. 9377-81
Abstract:Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Here we establish a role for the Clock gene in regulating the brain's reward circuit. Mice lacking a functional Clock gene display an increase in cocaine reward and in the excitability of dopamine neurons in the midbrain ventral tegmental area, a key brain reward region. These phenotypes are associated with increased expression and phosphorylation of tyrosine hydroxylase (the rate-limiting enzyme in dopamine synthesis), as well as changes in several genes known to regulate dopamine activity in the ventral tegmental area. These findings demonstrate the involvement of a circadian-associated gene, Clock, in regulating dopamine function and cocaine reward.   PUBMED: 15967985
Ontological Annotations:
  • D001927: Brain Diseases (Publication, NCBO Annotator)
  • D004298: Dopamine (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D008959: Models, Neurological (PubMed MeSH Annotations)
  • D011595: Psychomotor Agitation (Publication, NCBO Annotator)
  • D020411: Oligonucleotide Array Sequence Analysis (PubMed MeSH Annotations)
  • D015534: Trans-Activators (PubMed MeSH Annotations)
  • D000818: Animals (PubMed MeSH Annotations)
  • D015153: Blotting, Western (PubMed MeSH Annotations)
  • D014443: Tyrosine (Publication, NCBO Annotator)
  • D012201: Reward (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • MA:0000207: midbrain (Publication, NCBO Annotator)
  • D004364: Pharmaceutical Preparations (Publication, NCBO Annotator)
  • D004305: Dose-Response Relationship, Drug (PubMed MeSH Annotations)
  • MP:0002555: addiction (Publication, NCBO Annotator)
  • D017557: Ventral Tegmental Area (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • D004798: Enzymes (Publication, NCBO Annotator)
  • D014446: Tyrosine 3-Monooxygenase (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D016739: Behavior, Addictive (Publication, NCBO Annotator)
  • D007150: Immunohistochemistry (PubMed MeSH Annotations)
  • D009154: Mutation (PubMed MeSH Annotations)
  • D003042: Cocaine (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D002940: Circadian Rhythm (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D019966: Substance-Related Disorders (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D001007: Anxiety (Publication, NCBO Annotator)
  • D006899: Mixed Function Oxygenases (Publication, NCBO Annotator)
  • D006948: Hyperkinesis (Publication, NCBO Annotator)
  • D017354: Point Mutation (PubMed MeSH Annotations)
  • D010766: Phosphorylation (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D051379: Mice (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D009474: Neurons (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D007508: Irritable Mood (Publication, NCBO Annotator)
  • GO:0016310: phosphorylation (Publication, NCBO Annotator)
  • D008636: Mesencephalon (Publication, NCBO Annotator)
  • D001921: Brain (PubMed MeSH Annotations; Publication, NCBO Annotator)
  • D006720: Homozygote (PubMed MeSH Annotations)
  • D008822: Mice, Transgenic (PubMed MeSH Annotations)
  • D056926: CLOCK Proteins (PubMed MeSH Annotations)
  • D004594: Electrophysiology (PubMed MeSH Annotations)
  • D012380: Role (Publication, NCBO Annotator)
  • D010641: Phenotype (PubMed MeSH Annotations)
  • D013997: Time Factors (PubMed MeSH Annotations)

2 GeneSets from this Publication:


Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier I Mouse DRG 113 Genes provisional GS86670: Table S2: Genes regulated in the VTA of Clock mutant mice Genes up-regulated in the VTA of Clock mutant mice vs littermate controls [DRG]
Expand Tier I Mouse DRG 87 Genes provisional GS86875: Table S2: Genes regulated in the VTA of Clock mutant mice Genes down-regulated in the VTA of Clock mutant mice vs littermate controls [DRG]