Publication Details

Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice.

Authors:Mountz JD, Yang P, Wu Q, Zhou J, Tousson A, Fitzgerald A, Allen J, Wang X, Cartner S, Grizzle WE, Yi N, Lu L, Williams RW, Hsu HC
Title:Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice.
Journal:Scandinavian journal of immunology Feb 2005 , Vol 61 , pp. 128-38
Abstract:The BXD2 strain of mice is one of approximately 80 BXD recombinant inbred (RI) mouse strains derived from an intercross between C57BL/6J (B6) and DBA/2J (D2) strains. We have discovered that adult BXD2 mice spontaneously develop generalized autoimmune disease, including glomerulonephritis (GN), increased serum titres of rheumatoid factor (RF) and anti-DNA antibody, and a spontaneous erosive arthritis characterized by mononuclear cell infiltration, synovial hyperplasia, and bone and cartilage erosion. The features of lupus and arthritis developed by the BXD2 mice segregate in F2 mice generated by crossing BXD2 mice with the parental B6 and D2 strains. Genetic linkage analysis of the serum levels of anti-DNA and RF by using the BXD RI strains shows that the serum titers of anti-DNA and RF were influenced by a genetic locus on mouse chromosome (Chr) 2 near the marker D2Mit412 (78 cm, 163 Mb) and on Chr 4 near D4Mit146 (53.6 cm, 109 Mb), respectively. Both loci are close to the B-cell hyperactivity, lupus or GN susceptibility loci that have been identified previously. The results of our study suggest that the BXD2 strain of mice is a novel model for complex autoimmune disease that will be useful in identifying the mechanisms critical for the immunopathogenesis and genetic segregation of lupus and erosive arthritis.   PUBMED: 15683449
Ontological Annotations:
  • D044967: Serum (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • MP:0002743: glomerulonephritis (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D001402: B-Lymphocytes (Publication, NCBO Annotator)
  • D012217: Rheumatoid Factor (Publication, NCBO Annotator)
  • D008040: Genetic Linkage (Publication, NCBO Annotator)
  • D006965: Hyperplasia (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D005921: Glomerulonephritis (Publication, NCBO Annotator)
  • D011287: Prejudice (Publication, NCBO Annotator)
  • D001168: Arthritis (Publication, NCBO Annotator)
  • GO:0042571: immunoglobulin complex, circulating (Publication, NCBO Annotator)
  • D008815: Mice, Inbred Strains (Publication, NCBO Annotator)
  • D001327: Autoimmune Diseases (Publication, NCBO Annotator)
  • D002356: Cartilage (Publication, NCBO Annotator)
  • D002477: Cells (Publication, NCBO Annotator)
  • D056426: Genetic Loci (Publication, NCBO Annotator)
  • D000328: Adult (Publication, NCBO Annotator)
  • GO:0005623: cell (Publication, NCBO Annotator)
  • MA:0002502: serum (Publication, NCBO Annotator)
  • D001842: Bone and Bones (Publication, NCBO Annotator)
  • MA:0001459: bone (Publication, NCBO Annotator)
  • MP:0001399: hyperactivity (Publication, NCBO Annotator)
  • MP:0002993: arthritis (Publication, NCBO Annotator)

2 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 588 Genes GS135808: erosive arthritis susceptibility 1 (Erars1, Published QTL Chr 2)
Expand Tier II Mouse 616 Genes GS135809: erosive arthritis susceptibility 2 (Erars2, Published QTL Chr 4)