Publication Details

Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice.

Authors:Yi N, Chiu S, Allison DB, Fisler JS, Warden CH
Title:Epistatic interaction between two nonstructural loci on chromosomes 7 and 3 influences hepatic lipase activity in BSB mice.
Journal:Journal of lipid research Nov 2004 , Vol 45 , pp. 2063-70
Abstract:BSB mice exhibit a wide range of obesity despite being produced by a backcross of lean C57BL/6J (B) x lean Mus spretus (SPRET/Pt) F1 animals x B. Previous linkage studies identified a quantitative trait locus (QTL) on mouse chromosome 7 with coincident peaks for hepatic lipase activity, obesity, and plasma cholesterol. However, these mice were not analyzed for gene x gene epistasis. Hepatic lipase activity is correlated with obesity and plasma cholesterol levels. In this study, we identified QTLs for plasma hepatic lipase activity with three statistical mapping methods: maximum likelihood interval mapping, Bayesian nonepistatic mapping, and Bayesian epistatic mapping. Bayesian epistatic mapping detected not only the QTL on chromosome 7 but also an additional QTL on chromosome 3, which has a weak main effect but a strong interaction with chromosome 7. SPRET/Pt alleles of the QTL on each chromosome promote hepatic lipase activity. The proportion of phenotypic variance explained by the epistatic effect is higher than that explained by the main effect of the QTL on chromosome 7.   PUBMED: 15314098
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D008049: Lipase (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • MA:0002501: plasma (Publication, NCBO Annotator)
  • D002784: Cholesterol (Publication, NCBO Annotator)
  • GO:0016298: lipase activity (Publication, NCBO Annotator)
  • D002893: Chromosomes, Human, Pair 3 (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • MP:0001261: obese (Publication, NCBO Annotator)
  • D010949: Plasma (Publication, NCBO Annotator)
  • D002897: Chromosomes, Human, Pair 7 (Publication, NCBO Annotator)
  • D000818: Animals (Publication, NCBO Annotator)
  • D009765: Obesity (Publication, NCBO Annotator)
  • D008722: Methods (Publication, NCBO Annotator)
  • D000483: Alleles (Publication, NCBO Annotator)

2 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 612 Genes GS135999: hepatic lipase activity in BSB 1 (Hlbsb1, Published QTL Chr 7)
Expand Tier II Mouse 218 Genes GS136000: hepatic lipase activity in BSB 2 (Hlbsb2, Published QTL Chr 3)