Publication Details

Characterization of epistasis influencing complex spontaneous obesity in the BSB model.

Authors:Yi N, Diament A, Chiu S, Kim K, Allison DB, Fisler JS, Warden CH
Title:Characterization of epistasis influencing complex spontaneous obesity in the BSB model.
Journal:Genetics May 2004 , Vol 167 , pp. 399-409
Abstract:There is growing awareness that complex interactions among multiple genes and environmental factors play an important role in controlling obesity traits. The BSB mouse, which is produced by the backcross of (lean C57BL/6J x lean Mus spretus) x C57BL/6J, provides an excellent model of epistatic obesity. To evaluate potential epistatic interactions among six chromosomal regions previously determined to influence obesity phenotypes, we performed novel Bayesian analyses on the basis of both epistatic and nonepistatic models for four obesity traits: percentage of body fat, adiposity index, total fat mass, and body weight, and also for plasma total cholesterol. The epistatic analysis detected at least one more QTL than the nonepistatic analysis did for all obesity traits. These obesity traits were variously influenced by QTL on chromosomes 2, 7, 12, 15, and 16. Interaction between genes on chromosomes 2 and 12 was present for all obesity traits, accounting for 3-4.8% of the phenotypic variation. Chromosome 12 was found to have weak main effects on all obesity traits. Several different epistatic interactions were also detected for percentage of body fat, adiposity index, and total fat mass. Chromosomes 6 and 12 have not only main effects but also strong epistatic effects on plasma total cholesterol. Our results emphasize the importance of modeling epistasis for discovery of obesity genes.   PUBMED: 15166164
Ontological Annotations:
  • D001364: Awareness (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D001835: Body Weight (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D000066: Accounting (Publication, NCBO Annotator)
  • MA:0002501: plasma (Publication, NCBO Annotator)
  • D002784: Cholesterol (Publication, NCBO Annotator)
  • D000273: Adipose Tissue (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D050154: Adiposity (Publication, NCBO Annotator)
  • MP:0001261: obese (Publication, NCBO Annotator)
  • D010988: Play and Playthings (Publication, NCBO Annotator)
  • D010949: Plasma (Publication, NCBO Annotator)
  • D009765: Obesity (Publication, NCBO Annotator)
  • D012380: Role (Publication, NCBO Annotator)
  • D002881: Chromosomes, Human, Pair 12 (Publication, NCBO Annotator)
  • MA:0000009: adipose tissue (Publication, NCBO Annotator)

3 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 441 Genes GS135497: BSB obesity 3 (Bsbob3, Published QTL Chr 6)
Expand Tier II Mouse 409 Genes GS135498: BSB obesity 4 (Bsbob4, Published QTL Chr 12)
Expand Tier II Mouse 196 Genes GS135499: BSB obesity 5 (Bsbob5, Published QTL Chr 15)