Publication Details

Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population.

Authors:Korstanje R, Li R, Howard T, Kelmenson P, Marshall J, Paigen B, Churchill G
Title:Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population.
Journal:Journal of lipid research May 2004 , Vol 45 , pp. 881-8
Abstract:To investigate the dependence of HDL quantitative trait loci (QTL) on sex and diet, we generated a large intercross population of mice from parental strains SM/J and NZB/BlNJ. We measured HDL levels in progeny fed a chow diet and measured them again after 6, 12, and 16 weeks of feeding a high-fat, high-cholesterol diet. QTL analysis was performed on the 260 female and 253 male F(2) progeny. A total of 13 significant QTL were found. Four QTL were specific to female mice: Hdlq23 (Chr 6, 26 cM), Hdlq26 (Chr 10, 70 cM), Hdlq27 (Chr 15, 48 cM), and Hdlq32 (Chr 19, 40 cM). One significant QTL was specific to male mice: Hdlq29 (Chr 17, 36 cM). In addition, several QTL were found to have effects that were dependent on diet. Sex- and diet-dependent effects were characterized using a linear model-based genome scan method that avoids the potential pitfalls of subdivided data analysis. The dependence of QTL effects on sex suggests an important role for the sex hormones in HDL regulation. We recommend that sex should be explicitly accounted for in future studies in the genetics of HDL regulation in both mice and humans.   PUBMED: 14993241
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D008076: Cholesterol, HDL (Publication, NCBO Annotator)
  • D006801: Humans (Publication, NCBO Annotator)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D013223: Statistics as Topic (Publication, NCBO Annotator)
  • D002784: Cholesterol (Publication, NCBO Annotator)
  • D004032: Diet (Publication, NCBO Annotator)
  • D005544: Forecasting (Publication, NCBO Annotator)
  • D012723: Sex (Publication, NCBO Annotator)
  • D006728: Hormones (Publication, NCBO Annotator)
  • D005823: Genetics (Publication, NCBO Annotator)
  • D012739: Gonadal Steroid Hormones (Publication, NCBO Annotator)
  • D012380: Role (Publication, NCBO Annotator)

10 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 583 Genes GS135952: HDL QTL 2 (Hdlq2, Published QTL Chr 5)
Expand Tier II Mouse 354 Genes GS135955: HDL QTL 22 (Hdlq22, Published QTL Chr 5)
Expand Tier II Mouse 457 Genes GS135956: HDL QTL 23 (Hdlq23, Published QTL Chr 6)
Expand Tier II Mouse 258 Genes GS135958: HDL QTL 25 (Hdlq25, Published QTL Chr 8)
Expand Tier II Mouse 300 Genes GS135959: HDL QTL 26 (Hdlq26, Published QTL Chr 10)
Expand Tier II Mouse 674 Genes GS135960: HDL QTL 27 (Hdlq27, Published QTL Chr 15)
Expand Tier II Mouse 482 Genes GS135961: HDL QTL 28 (Hdlq28, Published QTL Chr 16)
Expand Tier II Mouse 643 Genes GS135962: HDL QTL 29 (Hdlq29, Published QTL Chr 17)
Expand Tier II Mouse 201 Genes GS135963: HDL QTL 31 (Hdlq31, Published QTL Chr 18)
Expand Tier II Mouse 392 Genes GS135964: HDL QTL 32 (Hdlq32, Published QTL Chr 19)