Publication Details

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.

Authors:Hoebe K, Janssen EM, Kim SO, Alexopoulou L, Flavell RA, Han J, Beutler B
Title:Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.
Journal:Nature immunology Dec 2003 , Vol 4 , pp. 1223-9
Abstract:Both lipopolysaccharide (LPS) and double-stranded RNA (dsRNA) are adjuvants for the adaptive immune response, inducing upregulation of costimulatory molecules (UCM) on antigen-presenting cells. Trif, an adapter protein that transduces signals from Toll-like receptor 4 (TLR4) and TLR3, permits the induction of many cytokines, including interferon-beta, which signals through the type I interferon receptor. We show here that LPS-induced UCM was strictly dependent on the TLR4-->Trif axis, whereas dsRNA-induced UCM was only partly dependent on the TLR3-->Trif axis. But both LPS- and dsRNA-induced UCM were entirely dependent on type I interferon receptor signaling. These findings show that UCM involves an autocrine or paracrine loop, and indicate that an alternative TLR3-independent, Trif-independent pathway contributes to dsRNA-induced UCM.   PUBMED: 14625548
Ontological Annotations:
  • GO:0023052: signaling (Publication, NCBO Annotator)
  • D015854: Up-Regulation (Publication, NCBO Annotator)
  • D016899: Interferon-beta (Publication, NCBO Annotator)
  • D053633: Receptor, Interferon alpha-beta (Publication, NCBO Annotator)
  • GO:0006955: immune response (Publication, NCBO Annotator)
  • GO:0002250: adaptive immune response (Publication, NCBO Annotator)
  • D017471: Receptors, Interferon (Publication, NCBO Annotator)
  • D016207: Cytokines (Publication, NCBO Annotator)
  • D012330: RNA, Double-Stranded (Publication, NCBO Annotator)
  • D002477: Cells (Publication, NCBO Annotator)
  • D007372: Interferons (Publication, NCBO Annotator)
  • D056704: Adaptive Immunity (Publication, NCBO Annotator)
  • D007370: Interferon Type I (Publication, NCBO Annotator)
  • D001368: Axis (Publication, NCBO Annotator)
  • D000938: Antigen-Presenting Cells (Publication, NCBO Annotator)
  • D012313: RNA (Publication, NCBO Annotator)
  • D051193: Toll-Like Receptors (Publication, NCBO Annotator)
  • D008004: Licensure (Publication, NCBO Annotator)
  • D051197: Toll-Like Receptor 4 (Publication, NCBO Annotator)

1 GeneSets from this Publication:


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Expand Tier I Mouse 473 Genes GS135740: dsRNA-induced UCM 1 (Ducm1, Published QTL Chr 7)