Publication Details

Spallanzani\'s mouse: a model of restoration and regeneration.

Authors:Heber-Katz E, Leferovich JM, Bedelbaeva K, Gourevitch D
Title:Spallanzani\'s mouse: a model of restoration and regeneration.
Journal:Current topics in microbiology and immunology 2004 , Vol 280 , pp. 165-89
Abstract:The ability to regenerate is thought to be a lost phenotype in mammals, though there are certainly sporadic examples of mammalian regeneration. Our laboratory has identified a strain of mouse, the MRL mouse, which has a unique capacity to heal complex tissue in an epimorphic fashion, i.e., to restore a damaged limb or organ to its normal structure and function. Initial studies using through-and-through ear punches showed rapid full closure of the ear holes with cartilage growth, new hair follicles, and normal tissue architecture reminiscent of regeneration seen in amphibians as opposed to the scarring usually seen in mammals. Since the ear hole closure phenotype is a quantitative trait, this has been used to show-through extensive breeding and backcrossing--that the trait is heritable. Such analysis reveals that there is a complex genetic basis for this trait with multiple loci. One of the major phenotypes of the MRL mouse is a potent remodeling response with the absence or a reduced level of scarring. MRL healing is associated with the upregulation of the metalloproteinases MMP-2 and MMP-9 and the downregulation of their inhibitors TIMP-2 and TIMP-3, both present in inflammatory cells such as neutrophils and macrophages. This model has more recently been extended to the heart. In this case, a cryoinjury to the right ventricle leads to near complete scarless healing in the MRL mouse whereas scarring is seen in the control mouse. In the MRL heart, bromodeoxyuridine uptake by cardiomyocytes filling the wound site can be seen 60 days after injury. This does not occur in the control mouse. Function in the MRL heart, as measured by echocardiography, returns to normal.   PUBMED: 14594211
Ontological Annotations:
  • MA:0000236: ear (Publication, NCBO Annotator)
  • D019716: Tissue Inhibitor of Metalloproteinase-2 (Publication, NCBO Annotator)
  • D001947: Breeding (Publication, NCBO Annotator)
  • D012038: Regeneration (Publication, NCBO Annotator)
  • D004423: Ear (Publication, NCBO Annotator)
  • D015854: Up-Regulation (Publication, NCBO Annotator)
  • D000663: Amphibians (Publication, NCBO Annotator)
  • D019717: Tissue Inhibitor of Metalloproteinase-3 (Publication, NCBO Annotator)
  • D009504: Neutrophils (Publication, NCBO Annotator)
  • D045726: Metalloproteases (Publication, NCBO Annotator)
  • D006352: Heart Ventricles (Publication, NCBO Annotator)
  • D001076: Aptitude (Publication, NCBO Annotator)
  • D007753: Laboratories (Publication, NCBO Annotator)
  • D014947: Wounds and Injuries (Publication, NCBO Annotator)
  • D006197: Hair (Publication, NCBO Annotator)
  • GO:0031099: regeneration (Publication, NCBO Annotator)
  • D015536: Down-Regulation (Publication, NCBO Annotator)
  • D002356: Cartilage (Publication, NCBO Annotator)
  • D005121: Extremities (Publication, NCBO Annotator)
  • D002477: Cells (Publication, NCBO Annotator)
  • D008322: Mammals (Publication, NCBO Annotator)
  • D006128: Growth (Publication, NCBO Annotator)
  • D008264: Macrophages (Publication, NCBO Annotator)
  • MA:0000007: limb (Publication, NCBO Annotator)
  • D004452: Echocardiography (Publication, NCBO Annotator)
  • D002921: Cicatrix (Publication, NCBO Annotator)
  • D032383: Myocytes, Cardiac (Publication, NCBO Annotator)
  • MA:0000072: heart (Publication, NCBO Annotator)
  • D018859: Hair Follicle (Publication, NCBO Annotator)
  • D009938: Organizations (Publication, NCBO Annotator)
  • D014024: Tissues (Publication, NCBO Annotator)
  • GO:0040007: growth (Publication, NCBO Annotator)
  • D006321: Heart (Publication, NCBO Annotator)
  • D001108: Architecture as Topic (Publication, NCBO Annotator)
  • D001973: Bromodeoxyuridine (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)

12 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 586 Genes GS135972: wound healing/regeneration 1 (Heal1, Published QTL Chr 8)
Expand Tier II Mouse 339 Genes GS135974: wound healing/regeneration 11 (Heal11, Published QTL Chr 16)
Expand Tier II Mouse 374 Genes GS135976: wound healing/regeneration 3 (Heal3, Published QTL Chr 13)
Expand Tier II Mouse 612 Genes GS135977: wound healing/regeneration 4 (Heal4, Published QTL Chr 15)
Expand Tier II Mouse 408 Genes GS135978: wound healing/regeneration 5 (Heal5, Published QTL Chr 12)
Expand Tier II Mouse 786 Genes GS135979: wound healing/regeneration 6 (Heal6, Published QTL Chr 7)
Expand Tier II Mouse 348 Genes GS135981: wound healing/regeneration 8 (Heal8, Published QTL Chr 13)
Expand Tier II Mouse 268 Genes GS135982: wound healing/regeneration 9 (Heal9, Published QTL Chr 18)
Expand Tier II Mouse 362 Genes GS136759: soft tissue heal 3 (Stheal3, Published QTL Chr 4)
Expand Tier II Mouse 351 Genes GS136761: soft tissue heal 5 (Stheal5, Published QTL Chr 6)
Expand Tier II Mouse 786 Genes GS136762: soft tissue heal 6 (Stheal6, Published QTL Chr 7)
Expand Tier II Mouse 491 Genes GS136763: soft tissue heal 7 (Stheal7, Published QTL Chr 7)