Publication Details

Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10.

Authors:Hsu HC, Zhang HG, Li L, Yi N, Yang PA, Wu Q, Zhou J, Sun S, Xu X, Yang X, Lu L, Van Zant G, Williams RW, Allison DB, Mountz JD
Title:Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10.
Journal:Genes and immunity Sep 2003 , Vol 4 , pp. 402-10
Abstract:A comprehensive analysis of initial thymus size and involution rate has not been quantitated for different genetic backgrounds of mice, thus genetic linkage analysis of thymic involution has not been possible. Here, we have used a mathematical method to analyze the age-related decline in thymocyte count in C57BL/6 and DBA/2 mice and have observed that thymic involution could be best fit with a negative exponential curve N(t)=beta(0) x exp(-beta(1)t), where t represents the age (day). This regression model was applied to C57BL/6 x DBA/2 (B x D) recombinant inbred strains of mice to identify the genetic loci influencing age-related thymic involution. There was a dramatic genetic effect of B and D alleles on thymocyte count at young age and the age-related thymic involution rate. The strongest quantitative trait loci (QTL) influencing the rate of thymic involution were mapped to mouse chromosome (Chr) 9 (D9Mit20 at 62 cM) and Chr 10 (D10Mit61 at 32 cM). The strongest QTLs influencing the initial thymocyte count were mapped to ChrX (DXMit324 at 26.5 cM) and Chr 3 (D3Mit127 at 70.3 cM). The present study suggests that the initial thymus size and the rate of thymic involution may be influenced by a relatively small number of genetic loci.   PUBMED: 12944977
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D019532: Maps (Publication, NCBO Annotator)
  • D056426: Genetic Loci (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D008040: Genetic Linkage (Publication, NCBO Annotator)
  • D013950: Thymus Gland (Publication, NCBO Annotator)
  • MA:0000142: thymus (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D012043: Regression (Psychology) (Publication, NCBO Annotator)
  • D008815: Mice, Inbred Strains (Publication, NCBO Annotator)
  • D000483: Alleles (Publication, NCBO Annotator)

4 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 437 Genes GS135325: age related thymic involution 1 (Arti1, Published QTL Chr 9)
Expand Tier II Mouse 538 Genes GS135326: age related thymic involution 2 (Arti2, Published QTL Chr 10)
Expand Tier II Mouse 323 Genes GS136824: thymocyte count 1 (Thyct1, Published QTL Chr X)
Expand Tier II Mouse 240 Genes GS136825: thymocyte count 2 (Thyct2, Published QTL Chr 3)