Publication Details

Genetic loci contributing to age-related hippocampal lesions in mice.

Authors:Krass KL, Colinayo V, Ghazalpour A, Vinters HV, Lusis AJ, Drake TA
Title:Genetic loci contributing to age-related hippocampal lesions in mice.
Journal:Neurobiology of disease Jul 2003 , Vol 13 , pp. 102-8
Abstract:C57BL/6J mice develop genetically determined age-related hippocampal granular deposits that have some similarities to lesions seen in the brains of human patients with tau protein related neurodegenerative disorders ("tauopathies"). We sought to identify the genetic loci responsible for these in an F2 intercross of inbred mouse strains C57BL/6J and DBA/2J, using quantitative trait locus (QTL) analysis. Hippocampal lesions were shown to be PAS positive, H and E negative, and immunoreactive for tau protein and alpha synuclein, but not to Abeta 1-40 or Abeta 1-42, or for ubiquitin. These were quantitated by histomorphometry, and QTL analysis revealed a locus on chromosome 7 with a lod score of 6.5 as well as two suggestive loci on chromosome 10. The genomic data indicate that the genetic basis is complex, but with one locus playing a major role in lesion formation. These lesions may represent a useful model for investigating dysregulation of tau protein in the hippocampus.   PUBMED: 12828934
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D006801: Humans (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D019636: Neurodegenerative Diseases (Publication, NCBO Annotator)
  • D051844: alpha-Synuclein (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D006624: Hippocampus (Publication, NCBO Annotator)
  • D016875: tau Proteins (Publication, NCBO Annotator)
  • GO:0000407: pre-autophagosomal structure (Publication, NCBO Annotator)
  • D051843: Synucleins (Publication, NCBO Annotator)
  • D008126: Lod Score (Publication, NCBO Annotator)
  • MA:0000191: hippocampus (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D002897: Chromosomes, Human, Pair 7 (Publication, NCBO Annotator)
  • D010361: Patients (Publication, NCBO Annotator)
  • D002879: Chromosomes, Human, Pair 10 (Publication, NCBO Annotator)
  • D025801: Ubiquitin (Publication, NCBO Annotator)
  • D008815: Mice, Inbred Strains (Publication, NCBO Annotator)
  • GO:0009058: biosynthetic process (Publication, NCBO Annotator)
  • D001921: Brain (Publication, NCBO Annotator)
  • D012380: Role (Publication, NCBO Annotator)
  • D056426: Genetic Loci (Publication, NCBO Annotator)

1 GeneSets from this Publication:

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Expand Tier II Mouse 445 Genes GS135897: granular brain lesions (Gbrln, Published QTL Chr 7)