Publication Details

NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci.

Authors:Waters ST, Fu SM, Gaskin F, Deshmukh US, Sung SS, Kannapell CC, Tung KS, McEwen SB, McDuffie M
Title:NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci.
Journal:Clinical immunology (Orlando, Fla.) Sep 2001 , Vol 100 , pp. 372-83
Abstract:Among NZB/W-derived New Zealand mixed (NZM) strains, only NZM/Aeg2410 (NZM2410) has been well characterized. In contrast to NZM2410, NZM2328 mice develop autoantibodies and acute and severe chronic glomerulonephritis (GN) with female predominance similarly to NZB/WF1 and humans with systemic lupus erythematosus (SLE). Chronic GN with glomerular sclerosis and tubular atrophy but not acute GN was correlated with severe proteinuria. In a backcross analysis of (NZM2328 X C57L/J) F1 X NZM2328, four SLE susceptibility genomic intervals were identified. One of them (Cgnz1) is on the telomeric end of chromosome 1 and close to Sle1. It was significantly linked to chronic GN. A locus (Agnz1) distinct from Cgnz1 on this interval was suggestively linked to acute GN. Two genetic intervals on chromosome 17 were also suggestively linked to acute GN, one of which is the H-2-Tnf complex, while the other (Agnz2) is on the distal end of the chromosome. A single locus (Adaz1) identified in the midregion of chromosome 4 in NZM2328 mice was suggestively linked to plasma levels of IgG anti-dsDNA autoantibodies. These results differ significantly from those in the backcross analysis of (NZM2410 X C57BL/6)F1 X NZM2410 by other investigators. They support the concept that different sets of genes are involved in acute and chronic GN. The genomic differences between the NZM strains and between C57L/J and C57BL/6 account for the differences between our analysis and that on NZM 2410. These results provide evidence for the importance of background genes on the expression of SLE, with implications for genetic studies of human SLE.   PUBMED: 11513551
Ontological Annotations:
  • D006801: Humans (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • MP:0002743: glomerulonephritis (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • MP:0005264: glomerulosclerosis (Publication, NCBO Annotator)
  • D008180: Lupus Erythematosus, Systemic (Publication, NCBO Annotator)
  • D002886: Chromosomes, Human, Pair 17 (Publication, NCBO Annotator)
  • D012598: Sclerosis (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D005921: Glomerulonephritis (Publication, NCBO Annotator)
  • D012108: Research Personnel (Publication, NCBO Annotator)
  • D002878: Chromosomes, Human, Pair 1 (Publication, NCBO Annotator)
  • D009520: New Zealand (Publication, NCBO Annotator)
  • D010949: Plasma (Publication, NCBO Annotator)
  • D002894: Chromosomes, Human, Pair 4 (Publication, NCBO Annotator)
  • D001284: Atrophy (Publication, NCBO Annotator)
  • D011507: Proteinuria (Publication, NCBO Annotator)
  • D007074: Immunoglobulin G (Publication, NCBO Annotator)
  • D001323: Autoantibodies (Publication, NCBO Annotator)
  • MA:0002501: plasma (Publication, NCBO Annotator)
  • D020022: Genetic Predisposition to Disease (Publication, NCBO Annotator)

2 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 440 Genes GS135242: anti-dsDNA antibody production in NZM 1 (Adaz1, Published QTL Chr 4)
Expand Tier II Mouse 460 Genes GS135583: chronic glomerulonephritis in NZM 1 (Cgnz1, Published QTL Chr 1)