Publication Details

Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs.

Authors:Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J Jr
Title:Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs.
Journal:Pharmacology, biochemistry, and behavior Dec 2000 , Vol 67 , pp. 767-72
Abstract:A genome-wide scan was conducted in two F(2) intercrosses, C57BL/6J (B6)xDBA/2J (D2) and BALB/cJ (C)xLP/J (LP), for three different phenotypes: basal locomotor activity, ethanol-induced locomotor activity, and haloperidol-induced catalepsy. For basal activity, significant quantitative trait loci (QTLs, LOD> or =4.3) were detected on chromosomes 9 and 19 for the CxLP intercross and chromosome 1 for the B6xD2 intercross. Significant QTLs for ethanol-induced activation were detected on chromosome 6 for the CxLP intercross, and on chromosomes 1 and 2 for the B6xD2 intercross. For haloperidol-induced catalepsy, significant QTLs were detected on chromosome 14 (two different QTLs) in the CxLP intercross, and chromosomes 1 and 9 in the B6xD2 intercross. These data illustrate the importance of the genetic cross for QTL detection. Finally, the data reported here, and elsewhere, are also used to demonstrate a novel approach to QTL detection and localization.   PUBMED: 11166067
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D003433: Crosses, Genetic (Publication, NCBO Annotator)
  • MP:0002822: catalepsy (Publication, NCBO Annotator)
  • GO:0051179: localization (Publication, NCBO Annotator)
  • D009043: Motor Activity (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D002878: Chromosomes, Human, Pair 1 (Publication, NCBO Annotator)
  • D002375: Catalepsy (Publication, NCBO Annotator)
  • D002896: Chromosomes, Human, Pair 6 (Publication, NCBO Annotator)
  • D002883: Chromosomes, Human, Pair 14 (Publication, NCBO Annotator)

4 GeneSets from this Publication:

Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier II Mouse 186 Genes GS84118: ethanol induced locomotion (Published QTL, Chr 1)
Expand Tier II Mouse 622 Genes GS84136: ethanol induced locomotion (Published QTL, Chr 2)
Expand Tier II Mouse 537 Genes GS84181: ethanol induced locomotion (Published QTL, Chr 6)
Expand Tier II Mouse 535 Genes GS136007: haloperidol-induced catalepsy 1 (Hpic1, Published QTL Chr 9)