Publication Details

Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross.

Authors:Koyner J, Demarest K, McCaughran J Jr, Cipp L, Hitzemann R
Title:Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross.
Journal:Behavior genetics May 2000 , Vol 30 , pp. 159-70
Abstract:A complimentary two-phase strategy was used to detect and map quantitative trait loci (QTLs) associated with the basal locomotor response to a saline challenge (10 ml/kg). In phase 1, putative QTLs, significant at p < 0.01 or better, were identified by analysis of the strain means for 25 strains of the B x D recombinant inbred series. QTLs were identified on chromosomes 1, 3, 5, 9, 10, 16, and 18. Some of these QTLs were detected across the entire experimental period (0-20 min), while others were associated with specific 5-min blocks. Eighteen hundred C57BL/6J (B6) x DBA/2J (D2) F2 intercross animals were phenotyped for the basal locomotor response, and of this group, 500 to 700 individuals, pseudo-randomly selected, were used for a genomewide scan to confirm the RI-generated QTLs and to detect new QTLs. No new QTLs were detected but the QTLs on chromosome 1 were confirmed at p < 10(-5) to p < 10(-9), depending on the time interval. In addition, the QTLs on chromosomes 5 and 9 were confirmed at p < 0.001, providing a combined probability (RI + F2) which exceeds the threshold for a significant association. Two additional phenotypes which showed significant RI strain differences were examined--adaptation and thigmotaxis. Adaptation mapped to the same region of chromosome 9 and thigmotaxis to the same region of chromosome 1 as the distance-traveled QTL. Overall, the data presented here and elsewhere (Flint et al., 1995; Gershenfeld et al., 1997) illustrate that QTLs for basal activity are both robust and reliable.   PUBMED: 11105390
Ontological Annotations:
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D007062: Identification (Psychology) (Publication, NCBO Annotator)
  • D016424: Overall (Publication, NCBO Annotator)
  • D002878: Chromosomes, Human, Pair 1 (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D013995: Time (Publication, NCBO Annotator)
  • D000818: Animals (Publication, NCBO Annotator)
  • D011336: Probability (Publication, NCBO Annotator)
  • D009043: Motor Activity (Publication, NCBO Annotator)
  • D002899: Chromosomes, Human, Pair 9 (Publication, NCBO Annotator)
  • D001244: Association (Publication, NCBO Annotator)
  • GO:0001966: thigmotaxis (Publication, NCBO Annotator)

4 GeneSets from this Publication:


Select gene sets below using the check boxes, and then add them to a project using the pull down below. You can also create a project using the pull down. To view a set, click on the GeneSetID:GeneSet Description shown in green below.
Expand Tier I Mouse 253 Genes GS135230: activity-distance traveled 1 (Actd1, Published QTL Chr 1)
Expand Tier I Mouse 357 Genes GS135231: activity-distance traveled 2 (Actd2, Published QTL Chr 5)
Expand Tier I Mouse 658 Genes GS135232: activity-distance traveled 3 (Actd3, Published QTL Chr 5)
Expand Tier I Mouse 605 Genes GS135233: activity-distance traveled 4 (Actd4, Published QTL Chr 9)