Publication Details

Epistatic modifiers of autoimmunity in a murine model of lupus nephritis.

Authors:Morel L, Tian XH, Croker BP, Wakeland EK
Title:Epistatic modifiers of autoimmunity in a murine model of lupus nephritis.
Journal:Immunity Aug 1999 , Vol 11 , pp. 131-9
Abstract:Sle1 and Sle3 are NZW-derived loci that mediate lupus nephritis on a C57BL/6 background. The absence of severe autoimmunity in NZW suggests that the NZW genome suppresses these genes. (B6.NZMc1[Sle1] x NZW)F1 hybrids develop severe humoral autoimmunity and fatal lupus nephritis, indicating that suppression of Sle1 from NZW is recessive. Linkage analysis identified four epistatic modifiers, Sles1-4, whose cumulative effect accounted for the benign autoimmunity in NZW. The specific suppression of Sle1 but not Sle2 or Sle3 by Sles1 was directly demonstrated via the production and analysis of bicongenic strains. Moreover, Sles1 was sufficient to completely suppress autoimmunity initiated by Sle1 in B6.NZMc1 x NZW hybrids. These results demonstrate the complex epistatic interactions of loci augmenting and suppressing systemic autoimmunity.   PUBMED: 10485648
Ontological Annotations:
  • MP:0001859: kidney inflammation (Publication, NCBO Annotator)
  • D002678: Chimera (Publication, NCBO Annotator)
  • D015551: Autoimmunity (Publication, NCBO Annotator)
  • D009393: Nephritis (Publication, NCBO Annotator)
  • D008181: Lupus Nephritis (Publication, NCBO Annotator)

2 GeneSets from this Publication:

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Expand Tier II Mouse 319 Genes GS136701: systemic lupus erythematosus susceptibility 6 (Sle6, Published QTL Chr 5)
Expand Tier II Mouse 758 Genes GS136705: systemic lupus erythmatosus suppressor 2 (Sles2, Published QTL Chr 4)