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Gene Set #84136 - ethanol induced locomotion (Published QTL, Chr 2)

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Description: ethanol induced locomotion spans 116.12 - 166.12 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI,
Uploaded: 01 Oct 2010
Species: Mus musculus
Authors: Hitzemann R, Demarest K, Koyner J, Cipp L, Patel N, Rasmussen E, McCaughran J Jr
Title: Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs.
Journal: Pharmacology, biochemistry, and behavior Dec 2000 , Vol 67 , pp. 767-72
Abstract: A genome-wide scan was conducted in two F(2) intercrosses, C57BL/6J (B6)xDBA/2J (D2) and BALB/cJ (C)xLP/J (LP), for three different phenotypes: basal locomotor activity, ethanol-induced locomotor activity, and haloperidol-induced catalepsy. For basal activity, significant quantitative trait loci (QTLs, LOD> or =4.3) were detected on chromosomes 9 and 19 for the CxLP intercross and chromosome 1 for the B6xD2 intercross. Significant QTLs for ethanol-induced activation were detected on chromosome 6 for the CxLP intercross, and on chromosomes 1 and 2 for the B6xD2 intercross. For haloperidol-induced catalepsy, significant QTLs were detected on chromosome 14 (two different QTLs) in the CxLP intercross, and chromosomes 1 and 9 in the B6xD2 intercross. These data illustrate the importance of the genetic cross for QTL detection. Finally, the data reported here, and elsewhere, are also used to demonstrate a novel approach to QTL detection and localization.   PUBMED: 11166067
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Ontological Associations:
  • D008124: Locomotion (GeneWeaver Primary Inferred; Description, NCBO Annotator)
  • D048088: Informatics (Description, NCBO Annotator)
  • D000431: Ethanol (Description, NCBO Annotator)
  • GO:0040011: locomotion (Description, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D002896: Chromosomes, Human, Pair 6 (Publication, NCBO Annotator)
  • D003433: Crosses, Genetic (Publication, NCBO Annotator)
  • MP:0002822: catalepsy (Publication, NCBO Annotator)
  • D002375: Catalepsy (Publication, NCBO Annotator)
  • D009043: Motor Activity (Publication, NCBO Annotator)
  • D002878: Chromosomes, Human, Pair 1 (Publication, NCBO Annotator)
  • D002883: Chromosomes, Human, Pair 14 (Publication, NCBO Annotator)
  • GO:0051179: localization (Publication, NCBO Annotator)

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