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Gene Set #36043 - Hippocampus Gene expression correlates of Light-Dark Box Total distance traveled in light and dark compartments in Males BXD

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Description: Hippocampus Gene Expression Correlates for LD_DISTANCE measured in BXD RI Males obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The LD_DISTANCE measures Light-Dark Box Total distance traveled in light and dark compartments under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Uploaded: 23 Mar 2010
Species: Mus musculus
Authors: Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Title: High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.
Journal: Genes, brain, and behavior Mar 2010 , Vol 9 , pp. 129-59
Abstract: Genetic reference populations, particularly the BXD recombinant inbred (BXD RI) strains derived from C57BL/6J and DBA/2J mice, are a valuable resource for the discovery of the bio-molecular substrates and genetic drivers responsible for trait variation and covariation. This approach can be profitably applied in the analysis of susceptibility and mechanisms of drug and alcohol use disorders for which many predisposing behaviors may predict the occurrence and manifestation of increased preference for these substances. Many of these traits are modeled by common mouse behavioral assays, facilitating the detection of patterns and sources of genetic coregulation of predisposing phenotypes and substance consumption. Members of the Tennessee Mouse Genome Consortium (TMGC) have obtained phenotype data from over 250 measures related to multiple behavioral assays across several batteries: response to, and withdrawal from cocaine, 3,4-methylenedioxymethamphetamine; \"ecstasy\" (MDMA), morphine and alcohol; novelty seeking; behavioral despair and related neurological phenomena; pain sensitivity; stress sensitivity; anxiety; hyperactivity and sleep/wake cycles. All traits have been measured in both sexes in approximately 70 strains of the recently expanded panel of BXD RI strains. Sex differences and heritability estimates were obtained for each trait, and a comparison of early (N = 32) and recent (N = 37) BXD RI lines was performed. Primary data are publicly available for heritability, sex difference and genetic analyses using the MouseTrack database, and are also available in GeneNetwork.org for quantitative trait locus (QTL) detection and genetic analysis of gene expression. Together with the results of related studies, these data form a public resource for integrative systems genetic analysis of neurobehavioral traits.   PUBMED: 19958391
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Ontological Associations:
  • D001522: Behavior, Animal (PubMed MeSH Annotations)
  • D008811: Mice, Inbred DBA (PubMed MeSH Annotations)
  • D006234: Handling (Psychology) (PubMed MeSH Annotations)
  • D006799: Housing, Animal (PubMed MeSH Annotations)
  • D001519: Behavior (Description, NCBO Annotator; Publication, NCBO Annotator)
  • D006297: Health Services Accessibility (Description, NCBO Annotator)
  • D006624: Hippocampus (Description, NCBO Annotator)
  • MA:0000191: hippocampus (Description, NCBO Annotator)
  • GO:0010467: gene expression (Description, NCBO Annotator; Publication, NCBO Annotator)
  • GO:0007610: behavior (Description, NCBO Annotator)
  • D010146: Pain (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator; PubMed MeSH Annotations)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D012723: Sex (Publication, NCBO Annotator)
  • D012727: Sex Characteristics (Publication, NCBO Annotator)
  • D003042: Cocaine (Publication, NCBO Annotator)
  • D013714: Tennessee (Publication, NCBO Annotator)
  • D009020: Morphine (Publication, NCBO Annotator)
  • D012890: Sleep (Publication, NCBO Annotator)
  • D001007: Anxiety (Publication, NCBO Annotator)
  • MP:0002573: behavioral despair (Publication, NCBO Annotator)
  • MP:0001399: hyperactivity (Publication, NCBO Annotator)
  • GO:0030431: sleep (Publication, NCBO Annotator)
  • D019966: Substance-Related Disorders (GeneWeaver Primary Inferred; PubMed MeSH Annotations)
  • D009929: Organ Size (PubMed MeSH Annotations)
  • D008810: Mice, Inbred C57BL (PubMed MeSH Annotations)
  • D011995: Recombination, Genetic (PubMed MeSH Annotations)
  • D001835: Body Weight (PubMed MeSH Annotations)
  • D006185: Habituation, Psychophysiologic (PubMed MeSH Annotations)
  • D000428: Alcohol Drinking (PubMed MeSH Annotations)
  • D010641: Phenotype (PubMed MeSH Annotations)
  • D000818: Animals (PubMed MeSH Annotations)
  • D009021: Morphine Dependence (PubMed MeSH Annotations)
  • D012333: RNA, Messenger (PubMed MeSH Annotations)
  • D019970: Cocaine-Related Disorders (PubMed MeSH Annotations)
  • D008027: Light (Description, NCBO Annotator)

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