GeneSet Details

The Gene Set Data and Analysis page enables you to translate gene sets across species, download gene set data, and use LinkOuts to learn more about specific genes. If you are the owner of a gene set you can edit the set from this page. Download and install GAGGLE Firegoose to send entire gene sets to other sites for analysis.

Gene Set #246374 - Differential Expression Hippocampus Human Cocaine Addicts

  • - Create New Project...
Description: Differential gene expression of RNA-Seq data for cocaine addicts. Gene Symbol and p-value (unadjusted). Samples were from twenty-three hippocampi from eight alcohol abusers, seven cocaine addicts,and eight matched control subjects.
Species: Homo sapiens
Authors: Farris SP, Harris RA, Ponomarev I
Title: Epigenetic modulation of brain gene networks for cocaine and alcohol abuse.
Journal: Frontiers in neuroscience 2015 , Vol 9 , pp. 176
Abstract: Cocaine and alcohol are two substances of abuse that prominently affect the central nervous system (CNS). Repeated exposure to cocaine and alcohol leads to longstanding changes in gene expression, and subsequent functional CNS plasticity, throughout multiple brain regions. Epigenetic modifications of histones are one proposed mechanism guiding these enduring changes to the transcriptome. Characterizing the large number of available biological relationships as network models can reveal unexpected biochemical relationships. Clustering analysis of variation from whole-genome sequencing of gene expression (RNA-Seq) and histone H3 lysine 4 trimethylation (H3K4me3) events (ChIP-Seq) revealed the underlying structure of the transcriptional and epigenomic landscape within hippocampal postmortem brain tissue of drug abusers and control cases. Distinct sets of interrelated networks for cocaine and alcohol abuse were determined for each abusive substance. The network approach identified subsets of functionally related genes that are regulated in agreement with H3K4me3 changes, suggesting cause and effect relationships between this epigenetic mark and gene expression. Gene expression networks consisted of recognized substrates for addiction, such as the dopamine- and cAMP-regulated neuronal phosphoprotein PPP1R1B/DARPP-32 and the vesicular glutamate transporter SLC17A7/VGLUT1 as well as potentially novel molecular targets for substance abuse. Through a systems biology based approach our results illustrate the utility of integrating epigenetic and transcript expression to establish relevant biological networks in the human brain for addiction. Future work with laboratory models may clarify the functional relevance of these gene networks for cocaine and alcohol, and provide a framework for the development of medications for the treatment of addiction.   PUBMED: 26041984
Find other GeneSets from this publication.

Gene List

Loading Gene List...