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Gene Set #224894 - Activity QTL 5 (Activ5 Published QTL Chr 16)

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Description: QTL Associated with Activity level. On Chromosome 16 with a LOD score= 3.78, p-value =2.80E-04. From a(n) F2 of reciprocal crosses of
Uploaded: 10 Jun 2015
Species: Rattus norvegicus
Authors: Redina OE, Smolenskaya SE, Maslova LN, Sakharov DG, Markel' AL
Title: The characteristics of motor activity in ISIAH rats in an open field test are controlled by genes on chromosomes 2 and 16.
Journal: Neuroscience and behavioral physiology , Vol 39 , pp. 57-64
Abstract: 1. Neurosci Behav Physiol. 2009 Jan;39(1):57-64. doi: 10.1007/s11055-008-9100-8. Epub 2008 Dec 17. The characteristics of motor activity in ISIAH rats in an open field test are controlled by genes on chromosomes 2 and 16. Redina OE(1), Smolenskaya SE, Maslova LN, Sakharov DG, Markel' AL. Author information: (1)Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia. oredina@bionet.nsc.ru Quantitative Trait Locus (QTL) analysis was used to identify the loci of polygenic characteristics in a study of the genetic determination of the behavior of rats with inherited stress-induced arterial hypertension (ISIAH rats). Analysis was performed using males of two populations of F2 hybrids (ISIAH x WAG) of different ages: 3-4 (n = 106) and six months (n = 130). Chromosomes 2 and 16 in the young population of F2 rats showed significant associations between two characteristics of behavior in ISIAH rats and genetic loci: a) the rats' motor activity at the periphery of the open field area with loci in the regions of markers D2Rat157-D2Rat88 (LOD score 4.83; p = 0.000058) and D16Rat32 (LOD score 3.71; p = 0.00023). Together, these two loci accounted for 42.9% of the trait variability; b) the rats' motor activity during the first minute of the open field test and loci in the region of the marker D16Rat58 (LOD score 3.78; p = 0.00028). Results obtained by QTL analysis demonstrated a relationship between the genetic control of these traits and the animals' age. PMID: 19089625 [PubMed - indexed for MEDLINE]   PUBMED: 19089625
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