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Gene Set #224672 - Aerobic running capacity QTL 4 (Arunc4 Published QTL Chr 16)

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Description: QTL Associated with Aerobic running capacity. On Chromosome 16 with a LOD score= , p-value =0.03. From a(n) of
Uploaded: 10 Jun 2015
Species: Rattus norvegicus
Authors: Ways JA, Smith BM, Barbato JC, Ramdath RS, Pettee KM, DeRaedt SJ, Allison DC, Koch LG, Lee SJ, Cicila GT
Title: Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes.
Journal: Physiological genomics , Vol 29 , pp. 91-7
Abstract: 1. Physiol Genomics. 2007 Mar 14;29(1):91-7. Epub 2006 Dec 19. Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes. Ways JA(1), Smith BM, Barbato JC, Ramdath RS, Pettee KM, DeRaedt SJ, Allison DC, Koch LG, Lee SJ, Cicila GT. Author information: (1)Departments of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo College of Medicine, Toledo, OH 43614, USA. We previously identified two inbred rat strains divergent for treadmill aerobic running capacity (ARC), the low-performing Copenhagen (COP) and the high-performing DA rats, and used an F(2)(COPxDA) population to identify ARC quantitative trait loci (QTLs) on rat chromosome 16 (RNO16) and the proximal portion of rat chromosome 3 (RNO3). Two congenic rat strains were bred to further investigate these ARC QTLs by introgressing RNO16 and the proximal portion of RNO3 from DA rats into the genetic background of COP rats and were named COP.DA(chr 16) and COP.DA(chr 3), respectively. COP.DA(chr 16) rats had significantly greater ARC compared with COP rats (696.7 +/- 38.2 m vs. 571.9 +/- 27.5 m, P = 0.03). COP.DA(chr 3) rats had increased, although not significant, ARC compared with COP rats (643.6 +/- 40.9 m vs. 571.9 +/- 27.5 m). COP.DA(chr 16) rats had significantly greater subcutaneous abdominal fat, as well as decreased fasting triglyceride levels, compared with COP rats (P < 0.05), indicating that genes responsible for strain differences in fat metabolism are also located on RNO16. While this colocalization of QTLs may be coincidental, it is also possible that these differences in energy balance may be associated with the superior running performance of COP.DA(chr 16) consomic rats. PMID: 17179209 [PubMed - indexed for MEDLINE]   PUBMED: 17179209
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