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Gene Set #223028 - Despair related QTL 2 (Despr2 Published QTL Chr 3)

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Description: QTL Associated with Activity level. On Chromosome 2 with a LOD score= , p-value =0.0035. From a(n) of QTL Associated with Activity level. On Chromosome 3 with a LOD score= , p-value =0.0028. From a(n) of
Uploaded: 10 Jun 2015
Species: Rattus norvegicus
Authors: Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Churchill GA, Takahashi JS, Redei EE
Title: Sex- and lineage-specific inheritance of depression-like behavior in the rat.
Journal: Mammalian genome : official journal of the International Mammalian Genome Society , Vol 15 , pp. 648-62
Abstract: 1. Mamm Genome. 2004 Aug;15(8):648-62. Sex- and lineage-specific inheritance of depression-like behavior in the rat. Solberg LC(1), Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Churchill GA, Takahashi JS, Redei EE. Author information: (1)Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, Illinois 60611, USA. The Wistar-Kyoto (WKY) rat exhibits physiological and behavioral similarities to endophenotypes of human depression. In the forced swim test (FST), a well-characterized antidepressant-reversible test for behavioral despair in rodents, WKYs express characteristics of behavioral despair; increased immobility, and decreased climbing. To map genetic loci linked to behavior in the FST, we conducted a quantitative trait loci (QTL) analysis of the segregating F2 generation of a WKY x Fisher 344 (F344) reciprocal intercross. Using linear-model-based genome scans to include covariate (sex or lineage)-by-QTL interaction effects, four significant QTL influencing climbing behavior were identified. In addition, we identified three, seven, and two suggestive QTL for climbing, immobility, and swimming, respectively. One of these loci was pleiotropic, affecting both immobility and climbing. As found in human linkage studies, several of these QTL showed sex- and/or lineage-dependent effects. A simultaneous search strategy identified three epistatic locus pairs for climbing. Multiple regression analysis was employed to characterize the joint contributions of these QTL and to clarify the sex- and lineage-dependent effects. As expected for complex traits, FST behavior is influenced by multiple QTL of small effect, each contributing 5%-10%, accounting for a total 10%-30% of the phenotypic variance. A number of loci mapped in this study share overlapping candidate regions with previously identified emotionality QTL in mice as well as with susceptibility loci recognized by linkage or genome scan analyses for major depression or bipolar disorder in humans. The presence of these loci across species suggests that these QTL may represent universal genetic factors contributing to mood disorders. PMCID: PMC3764448 PMID: 15457344 [PubMed - indexed for MEDLINE]   PUBMED: 15457344
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