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Gene Set #136903 - ventral midbrain iron content 9 (Vmbic9, Published QTL Chr 17)

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Description: QTL associated with ventral midbrain iron content 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45448429)
Uploaded: 02 Apr 2012
Species: Mus musculus
Authors: Jones LC, McCarthy KA, Beard JL, Keen CL, Jones BC
Title: Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice.
Journal: Nutritional neuroscience Feb-Apr 2006 , Vol 9 , pp. 81-92
Abstract: Copper and zinc are trace nutrients essential for normal brain function, yet an excess of these elements can be toxic. It is important therefore that these metals be closely regulated. We recently conducted a quantitative trait loci (QTL) analysis to identify chromosomal regions in the mouse containing possible regulatory genes. The animals came from 15 strains of the BXD/Ty recombinant inbred (RI) strain panel and the brain regions analyzed were frontal cortex, caudate-putamen, nucleus accumbens and ventral midbrain. Several QTL were identified for copper and/or zinc, most notably on chromosomes 1, 8, 16 and 17. Genetic correlational analysis also revealed associations between these metals and dopamine, cocaine responses, saccharine preference, immune response and seizure susceptibility. Notably, the QTL on chromosome 17 is also associated with seizure susceptibility and contains the histocompatibility H2 complex. This work shows that regulation of zinc and copper is under polygenic influence and is intimately related to CNS function. Future work will reveal genes underlying the QTL and how they interact with other genes and the environment. More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance.   PUBMED: 16910173
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Ontological Associations:
  • D008636: Mesencephalon (Description, NCBO Annotator; Publication, NCBO Annotator)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • D001921: Brain (Publication, NCBO Annotator)
  • D006706: Homeostasis (Publication, NCBO Annotator; GeneWeaver Primary Inferred)
  • D000818: Animals (Publication, NCBO Annotator)
  • D004777: Environment (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D002886: Chromosomes, Human, Pair 17 (Publication, NCBO Annotator)
  • D004298: Dopamine (Publication, NCBO Annotator)
  • D005502: Food (Publication, NCBO Annotator)
  • D008670: Metals (Publication, NCBO Annotator)
  • D003300: Copper (Publication, NCBO Annotator)
  • D003042: Cocaine (Publication, NCBO Annotator)
  • D004602: Elements (Publication, NCBO Annotator)
  • MA:0000168: brain (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • EDAM_data:1860: QTL map (GeneWeaver Data Type)
  • MA:0000207: midbrain (Description, NCBO Annotator; Publication, NCBO Annotator)
  • D032882: Comprehension (Publication, NCBO Annotator)
  • D007316: Insemination, Artificial, Heterologous (Publication, NCBO Annotator)
  • MA:0000893: caudate-putamen (Publication, NCBO Annotator)
  • GO:0006955: immune response (Publication, NCBO Annotator)
  • GO:0005634: nucleus (Publication, NCBO Annotator)
  • D006648: Histocompatibility (Publication, NCBO Annotator)
  • D014937: Work (Publication, NCBO Annotator)
  • D009714: Nucleus Accumbens (Publication, NCBO Annotator)
  • D015032: Zinc (Publication, NCBO Annotator)
  • D001244: Association (Publication, NCBO Annotator)
  • MA:0000905: frontal cortex (Publication, NCBO Annotator)
  • D007501: Iron (Description, NCBO Annotator)
  • D012640: Seizures (Publication, NCBO Annotator)
  • D005544: Forecasting (Publication, NCBO Annotator)
  • D005809: Genes, Regulator (Publication, NCBO Annotator)

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