GeneSet Details

The Gene Set Data and Analysis page enables you to translate gene sets across species, download gene set data, and use LinkOuts to learn more about specific genes. If you are the owner of a gene set you can edit the set from this page. Download and install GAGGLE Firegoose to send entire gene sets to other sites for analysis.

Gene Set #136469 - p-glycoprotein positive CD4 T cell subset 2 (Pcd4ts2, Published QTL Chr 13)

  • - Create New Project...
Description: QTL associated with p-glycoprotein positive CD4 T cell subset 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45152335)
Uploaded: 02 Apr 2012
Species: Mus musculus
URI: http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2661279
Authors: Jackson AU, Galecki AT, Burke DT, Miller RA
Title: Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets.
Journal: Genes and immunity Jan 2003 , Vol 4 , pp. 30-9
Abstract: To see whether genetic polymorphisms regulate inter-individual differences in T cell subset levels, we have conducted a genome scan in two populations of mice, bred as the progeny of a cross between CB6F1 females and C3D2F1 males. The data document quantitative trait loci (QTL) with statistically significant effects on CD4, CD8, and CD8 memory T cells, and on subsets of CD4 and CD8 T cells that express P-glycoprotein. Some of the loci detected were robust, in the sense that they produced effects of similar size both in mated female mice, and in a population that included male and female virgin animals. Some of the effects were stable, in that they were apparent at both 8 and 18 months of age, but others were age-specific, showing effects either at 8 or at 18 months but not at both ages. Genes that had an effect on the same T cell subset were in almost all cases additive rather than epistatic, and their combined effects could produce large overall effects, leading in the most dramatic case to a two-fold difference in CD8 memory cells. The analysis also documented two QTL, on chromosomes 4 and 13, that regulate an age-sensitive composite index of T cell subset pattern which has been shown previously to be a predictor of life expectancy in these mice. The analysis thus reveals both subset-specific genes and others which modulate the overall pattern of age-sensitive changes in T cell subset distributions.   PUBMED: 12595899
Find other GeneSets from this publication.
Ontological Associations:
  • D002477: Cells (Description, NCBO Annotator; Publication, NCBO Annotator)
  • D013601: T-Lymphocytes (Publication, NCBO Annotator)
  • D000818: Animals (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator; GeneWeaver Primary Inferred)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D011110: Polymorphism, Genetic (Publication, NCBO Annotator)
  • EDAM_data:1860: QTL map (GeneWeaver Data Type)
  • D019369: Life (Publication, NCBO Annotator)
  • D016424: Overall (Publication, NCBO Annotator)
  • D020168: P-Glycoprotein (Description, NCBO Annotator; Publication, NCBO Annotator)
  • D016176: T-Lymphocyte Subsets (Publication, NCBO Annotator)
  • GO:0007613: memory (Publication, NCBO Annotator)
  • GO:0005623: cell (Description, NCBO Annotator; Publication, NCBO Annotator)
  • D008568: Memory (Publication, NCBO Annotator)
  • D008017: Life Expectancy (Publication, NCBO Annotator)

Gene List


Loading Gene List...