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Gene Set #135958 - HDL QTL 25 (Hdlq25, Published QTL Chr 8)

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Description: QTL associated with HDL QTL 25. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (7162499)
Uploaded: 02 Apr 2012
Species: Mus musculus
URI: http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3041287
Authors: Korstanje R, Li R, Howard T, Kelmenson P, Marshall J, Paigen B, Churchill G
Title: Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population.
Journal: Journal of lipid research May 2004 , Vol 45 , pp. 881-8
Abstract: To investigate the dependence of HDL quantitative trait loci (QTL) on sex and diet, we generated a large intercross population of mice from parental strains SM/J and NZB/BlNJ. We measured HDL levels in progeny fed a chow diet and measured them again after 6, 12, and 16 weeks of feeding a high-fat, high-cholesterol diet. QTL analysis was performed on the 260 female and 253 male F(2) progeny. A total of 13 significant QTL were found. Four QTL were specific to female mice: Hdlq23 (Chr 6, 26 cM), Hdlq26 (Chr 10, 70 cM), Hdlq27 (Chr 15, 48 cM), and Hdlq32 (Chr 19, 40 cM). One significant QTL was specific to male mice: Hdlq29 (Chr 17, 36 cM). In addition, several QTL were found to have effects that were dependent on diet. Sex- and diet-dependent effects were characterized using a linear model-based genome scan method that avoids the potential pitfalls of subdivided data analysis. The dependence of QTL effects on sex suggests an important role for the sex hormones in HDL regulation. We recommend that sex should be explicitly accounted for in future studies in the genetics of HDL regulation in both mice and humans.   PUBMED: 14993241
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Ontological Associations:
  • EDAM_data:1860: QTL map (GeneWeaver Data Type)
  • D012926: Social Control, Formal (Publication, NCBO Annotator)
  • D006801: Humans (Publication, NCBO Annotator)
  • D005823: Genetics (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D012380: Role (Publication, NCBO Annotator)
  • D012723: Sex (Publication, NCBO Annotator)
  • D004032: Diet (Publication, NCBO Annotator)
  • D006728: Hormones (GeneWeaver Primary Inferred; Publication, NCBO Annotator)
  • D012739: Gonadal Steroid Hormones (Publication, NCBO Annotator)
  • D008076: Cholesterol, HDL (Publication, NCBO Annotator)
  • D002784: Cholesterol (Publication, NCBO Annotator)
  • D005544: Forecasting (Publication, NCBO Annotator)
  • D013223: Statistics as Topic (Publication, NCBO Annotator)

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