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Gene Set #135944 - HDL QTL 10 (Hdlq10, Published QTL Chr 4)

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Description: QTL associated with HDL QTL 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (52872579)
Uploaded: 02 Apr 2012
Species: Mus musculus
URI: http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2448343
Authors: Wittenburg H, Lyons MA, Li R, Kurtz U, Wang X, Mssner J, Churchill GA, Carey MC, Paigen B
Title: QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains.
Journal: Journal of lipid research Aug 2006 , Vol 47 , pp. 1780-90
Abstract: To identify additional loci that influence lipoprotein cholesterol levels, we performed quantitative trait locus (QTL) mapping in offspring of PERA/EiJxI/LnJ and PERA/EiJxDBA/2J intercrosses and in a combined data set from both crosses after 8 weeks of consumption of a high fat-diet. Most QTLs identified were concordant with homologous chromosomal regions that were associated with lipoprotein levels in human studies. We detected significant new loci for HDL cholesterol levels on chromosome (Chr) 5 (Hdlq34) and for non-HDL cholesterol levels on Chrs 15 (Nhdlq9) and 16 (Nhdlq10). In addition, the analysis of combined data sets identified a QTL for HDL cholesterol on Chr 17 that was shared between both crosses; lower HDL cholesterol levels were conferred by strain PERA. This QTL colocalized with a shared QTL for cholesterol gallstone formation detected in the same crosses. Haplotype analysis narrowed this QTL, and sequencing of the candidate genes Abcg5 and Abcg8 confirmed shared alleles in strains I/LnJ and DBA/2J that differed from the alleles in strain PERA/EiJ. In conclusion, our analysis furthers the knowledge of genetic determinants of lipoprotein cholesterol levels in inbred mice and substantiates the hypothesis that polymorphisms of Abcg5/Abcg8 contribute to individual variation in both plasma HDL cholesterol levels and susceptibility to cholesterol gallstone formation.   PUBMED: 16685081
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Ontological Associations:
  • EDAM_data:1860: QTL map (GeneWeaver Data Type)
  • D006801: Humans (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D008815: Mice, Inbred Strains (Publication, NCBO Annotator)
  • D006239: Haplotypes (Publication, NCBO Annotator)
  • GO:0009058: biosynthetic process (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D015211: Zellweger Syndrome (Publication, NCBO Annotator)
  • D012718: Set (Psychology) (Publication, NCBO Annotator)
  • D002784: Cholesterol (GeneWeaver Primary Inferred; Publication, NCBO Annotator)
  • D008076: Cholesterol, HDL (Publication, NCBO Annotator)
  • D042882: Gallstones (Publication, NCBO Annotator)
  • D010949: Plasma (Publication, NCBO Annotator)
  • MA:0002501: plasma (Publication, NCBO Annotator)
  • D000483: Alleles (Publication, NCBO Annotator)
  • D008074: Lipoproteins (Publication, NCBO Annotator)
  • D019359: Knowledge (Publication, NCBO Annotator)

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