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Gene Set #135918 - graft-versus host disease 3 (Gvhd3, Published QTL Chr 2)

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Description: QTL associated with graft-versus host disease 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (117938185)
Uploaded: 02 Apr 2012
Species: Mus musculus
URI: http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1858386
Authors: Harper JM, Slayback DL, Dobkins JA, Allen RD
Title: A locus on chromosome 2 influences the development of acute graft-versus-host disease in a murine model.
Journal: Bone marrow transplantation Jun 1999 , Vol 23 , pp. 1183-90
Abstract: Despite contemporary typing procedures for bone marrow transplantation (BMT), graft-versus-host disease (GVHD) continues to be a major complication of transplants performed between MHC-matched donors and recipients. Although GVHD can be alleviated by T cell depletion, this procedure increases the risk of graft failure and leukemic relapse and therefore is not a solution to the GVHD problem. The high degree of variation in the intensity of GVHD observed in different patients suggests that multiple non-MHC genetic factors influence GVHD severity. We hypothesize that, in addition to minor histocompatibility antigen disparities, polymorphisms in genes encoding immunologic effector molecules may be important factors influencing GVHD development. This study aims to explore this hypothesis by identifying non-MHC genes that influence the outcome of BMT in a murine model. In this model, B10.D2 donor leukocytes cause acute GVHD in (C57BL/6xDBA/2)F1 (B6D2F1) recipients, whereas DBA/2 donor leukocytes do not. To date, a locus on chromosome 1 has been identified as influencing the severity of GVHD in this model. Our current study shows that a locus on chromosome 2 acts independently of the chromosome 1 locus to also influence GVHD severity in this model. The region of chromosome 2 implicated in our study contains genes encoding beta2-microglobulin, the minor histocompatibility antigen H-3 and the pro-inflammatory cytokine IL-1.   PUBMED: 10382959
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Ontological Associations:
  • EDAM_data:1860: QTL map (GeneWeaver Data Type)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D010361: Patients (Publication, NCBO Annotator)
  • D000941: Antigens (Publication, NCBO Annotator; GeneWeaver Primary Inferred)
  • D007962: Leukocytes (Publication, NCBO Annotator)
  • D002889: Chromosomes, Human, Pair 2 (Publication, NCBO Annotator)
  • D019737: Transplants (Publication, NCBO Annotator)
  • D002477: Cells (Publication, NCBO Annotator)
  • D001842: Bone and Bones (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • D014019: Tissue Donors (Publication, NCBO Annotator)
  • D012008: Recurrence (Publication, NCBO Annotator)
  • D016026: Bone Marrow Transplantation (Publication, NCBO Annotator)
  • D012306: Risk (Publication, NCBO Annotator)
  • D001853: Bone Marrow (Publication, NCBO Annotator)
  • D033242: Minors (Publication, NCBO Annotator)
  • D002878: Chromosomes, Human, Pair 1 (Publication, NCBO Annotator)
  • D006648: Histocompatibility (Publication, NCBO Annotator)
  • GO:0018995: host (Description, NCBO Annotator)
  • D006649: Histocompatibility Antigens (Publication, NCBO Annotator)
  • D006086: Graft vs Host Disease (Publication, NCBO Annotator)
  • D014180: Transplantation (Publication, NCBO Annotator)
  • D007375: Interleukin-1 (Publication, NCBO Annotator)
  • D008722: Methods (Publication, NCBO Annotator)
  • MA:0001459: bone (Publication, NCBO Annotator)
  • MA:0000134: bone marrow (Publication, NCBO Annotator)
  • GO:0005623: cell (Publication, NCBO Annotator)

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