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Gene Set #135708 - diabetes susceptibility QTL 5 (Dbsq5, Published QTL Chr 2)

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Description: QTL associated with diabetes susceptibility QTL 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (112034799)
Uploaded: 02 Apr 2012
Species: Mus musculus
Authors: Moritani M, Togawa K, Yaguchi H, Fujita Y, Yamaguchi Y, Inoue H, Kamatani N, Itakura M
Title: Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping.
Journal: Genomics Dec 2006 , Vol 88 , pp. 719-30
Abstract: To identify the disease-susceptibility genes of type 2 diabetes, we performed quantitative trait loci (QTL) analysis in F(2) populations generated from a BKS.Cg-m+/+Lepr(db) and C3H/HeJ intercross, taking advantage of genetically determined obesity and diabetes traits associated with the db gene. A genome-wide scan in the F(2) populations divided by sex and db genotypes identified 14 QTLs in total and 3 major QTLs on chromosome (Chr) 3 (LOD 5.78) for fat pad weight, Chr 15 (LOD 6.64) for body weight, and Chr 16 (LOD 8.15) for blood glucose concentrations. A linear-model-based genome scan using interactive covariates allowed us to consider sex- or sex-by db-specific effects of each locus. For the most significant QTL on Chr 16, the high-resolution haplotype comparison between BKS and C3H strains reduced the critical QTL interval from 20 to 4.6 Mb by excluding shared haplotype regions and identified 11 nonsynonymous single-nucleotide polymorphisms in six candidate genes.   PUBMED: 16919419
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Ontological Associations:
  • D005947: Glucose (Publication, NCBO Annotator)
  • D051379: Mice (Publication, NCBO Annotator)
  • D002875: Chromosomes (Publication, NCBO Annotator)
  • D040641: Quantitative Trait Loci (Publication, NCBO Annotator)
  • D012723: Sex (Publication, NCBO Annotator)
  • D006239: Haplotypes (Publication, NCBO Annotator)
  • D001835: Body Weight (Publication, NCBO Annotator)
  • MA:0000009: adipose tissue (Publication, NCBO Annotator)
  • GO:0005694: chromosome (Publication, NCBO Annotator)
  • EDAM_data:1860: QTL map (GeneWeaver Data Type)
  • D005838: Genotype (Publication, NCBO Annotator)
  • D007062: Identification (Psychology) (Publication, NCBO Annotator)
  • MA:0002481: fat pad (Publication, NCBO Annotator)
  • MP:0001261: obese (Publication, NCBO Annotator)
  • D009765: Obesity (Publication, NCBO Annotator)
  • D001786: Blood Glucose (Publication, NCBO Annotator)
  • MA:0000059: blood (Publication, NCBO Annotator)
  • D001288: Attention (Publication, NCBO Annotator; GeneWeaver Primary Inferred)
  • D000273: Adipose Tissue (Publication, NCBO Annotator)
  • D001769: Blood (Publication, NCBO Annotator)

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